Impact of contrast agent viscosity on coronary balloon deflation times: Bench testing results

Owen Mogabgab, Vishal G. Patel, Tesfaldet T. Michael, Anna Kotsia, George Christopoulos, Subhash Banerjee, Emmanouil S. Brilakis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives To assess the impact of viscosity on angioplasty balloon deflation times. Background Lower contrast viscosity could result in more rapid coronary balloon deflation times. Methods We performed a bench comparison of coronary balloon deflation times using 2 contrast agents with different viscosity (ioxaglate and iodixanol), 3 contrast dilutions, and 2 inflation syringe filling volumes. Ten identical pairs of coronary angioplasty balloons were used to conduct each comparison after balloon inflation to 12 atmospheres. Simultaneous deflations were performed under cineangiography. The time to full contrast extraction and the area of contrast remaining after 5-seconds of deflation (quantified by opaque pixel count) were compared between groups. Results The mean time to full contrast extraction during balloon deflation was 8.3±2.5-seconds for ioxaglate (lower viscosity) versus 10.1±2.9-seconds for iodixanol (higher viscosity) (17.4% decrease, P=0.005), with a 35.6% (P=0.004) reduction in contrast area at 5-seconds. Compared to 1:1 ioxaglate-saline mixture, 1:2 and 1:3 ioxaglate/saline mixes resulted in 26.7% (P<0.001) and 39.0% (P<0.001) reduction in mean balloon deflation time, respectively, but at the expense of decreased balloon opacity. Filling the inflation syringe with 5 versus 15-ml of contrast/saline solution was associated with 7.5% decrease in balloon deflation time (P=0.005), but no difference in contrast area at 5-seconds (P=0.749). Conclusions Use of a lower viscosity contrast agent and higher contrast dilution significantly reduced coronary balloon deflation times, whereas use of lower syringe filling volume had a modest effect. Rapid coronary balloon deflation could improve the safety of interventional procedures.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalJournal of Interventional Cardiology
Volume27
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Viscosity
Contrast Media
Ioxaglic Acid
Economic Inflation
Syringes
Cineangiography
Coronary Balloon Angioplasty
Balloon Angioplasty
Atmosphere
Sodium Chloride
Safety

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Impact of contrast agent viscosity on coronary balloon deflation times : Bench testing results. / Mogabgab, Owen; Patel, Vishal G.; Michael, Tesfaldet T.; Kotsia, Anna; Christopoulos, George; Banerjee, Subhash; Brilakis, Emmanouil S.

In: Journal of Interventional Cardiology, Vol. 27, No. 2, 2014, p. 177-181.

Research output: Contribution to journalArticle

Mogabgab, Owen ; Patel, Vishal G. ; Michael, Tesfaldet T. ; Kotsia, Anna ; Christopoulos, George ; Banerjee, Subhash ; Brilakis, Emmanouil S. / Impact of contrast agent viscosity on coronary balloon deflation times : Bench testing results. In: Journal of Interventional Cardiology. 2014 ; Vol. 27, No. 2. pp. 177-181.
@article{b6fd7b5a760742a5923e53cf2a2ccc08,
title = "Impact of contrast agent viscosity on coronary balloon deflation times: Bench testing results",
abstract = "Objectives To assess the impact of viscosity on angioplasty balloon deflation times. Background Lower contrast viscosity could result in more rapid coronary balloon deflation times. Methods We performed a bench comparison of coronary balloon deflation times using 2 contrast agents with different viscosity (ioxaglate and iodixanol), 3 contrast dilutions, and 2 inflation syringe filling volumes. Ten identical pairs of coronary angioplasty balloons were used to conduct each comparison after balloon inflation to 12 atmospheres. Simultaneous deflations were performed under cineangiography. The time to full contrast extraction and the area of contrast remaining after 5-seconds of deflation (quantified by opaque pixel count) were compared between groups. Results The mean time to full contrast extraction during balloon deflation was 8.3±2.5-seconds for ioxaglate (lower viscosity) versus 10.1±2.9-seconds for iodixanol (higher viscosity) (17.4{\%} decrease, P=0.005), with a 35.6{\%} (P=0.004) reduction in contrast area at 5-seconds. Compared to 1:1 ioxaglate-saline mixture, 1:2 and 1:3 ioxaglate/saline mixes resulted in 26.7{\%} (P<0.001) and 39.0{\%} (P<0.001) reduction in mean balloon deflation time, respectively, but at the expense of decreased balloon opacity. Filling the inflation syringe with 5 versus 15-ml of contrast/saline solution was associated with 7.5{\%} decrease in balloon deflation time (P=0.005), but no difference in contrast area at 5-seconds (P=0.749). Conclusions Use of a lower viscosity contrast agent and higher contrast dilution significantly reduced coronary balloon deflation times, whereas use of lower syringe filling volume had a modest effect. Rapid coronary balloon deflation could improve the safety of interventional procedures.",
author = "Owen Mogabgab and Patel, {Vishal G.} and Michael, {Tesfaldet T.} and Anna Kotsia and George Christopoulos and Subhash Banerjee and Brilakis, {Emmanouil S.}",
year = "2014",
doi = "10.1111/joic.12097",
language = "English (US)",
volume = "27",
pages = "177--181",
journal = "Journal of Interventional Cardiology",
issn = "0896-4327",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Impact of contrast agent viscosity on coronary balloon deflation times

T2 - Bench testing results

AU - Mogabgab, Owen

AU - Patel, Vishal G.

AU - Michael, Tesfaldet T.

AU - Kotsia, Anna

AU - Christopoulos, George

AU - Banerjee, Subhash

AU - Brilakis, Emmanouil S.

PY - 2014

Y1 - 2014

N2 - Objectives To assess the impact of viscosity on angioplasty balloon deflation times. Background Lower contrast viscosity could result in more rapid coronary balloon deflation times. Methods We performed a bench comparison of coronary balloon deflation times using 2 contrast agents with different viscosity (ioxaglate and iodixanol), 3 contrast dilutions, and 2 inflation syringe filling volumes. Ten identical pairs of coronary angioplasty balloons were used to conduct each comparison after balloon inflation to 12 atmospheres. Simultaneous deflations were performed under cineangiography. The time to full contrast extraction and the area of contrast remaining after 5-seconds of deflation (quantified by opaque pixel count) were compared between groups. Results The mean time to full contrast extraction during balloon deflation was 8.3±2.5-seconds for ioxaglate (lower viscosity) versus 10.1±2.9-seconds for iodixanol (higher viscosity) (17.4% decrease, P=0.005), with a 35.6% (P=0.004) reduction in contrast area at 5-seconds. Compared to 1:1 ioxaglate-saline mixture, 1:2 and 1:3 ioxaglate/saline mixes resulted in 26.7% (P<0.001) and 39.0% (P<0.001) reduction in mean balloon deflation time, respectively, but at the expense of decreased balloon opacity. Filling the inflation syringe with 5 versus 15-ml of contrast/saline solution was associated with 7.5% decrease in balloon deflation time (P=0.005), but no difference in contrast area at 5-seconds (P=0.749). Conclusions Use of a lower viscosity contrast agent and higher contrast dilution significantly reduced coronary balloon deflation times, whereas use of lower syringe filling volume had a modest effect. Rapid coronary balloon deflation could improve the safety of interventional procedures.

AB - Objectives To assess the impact of viscosity on angioplasty balloon deflation times. Background Lower contrast viscosity could result in more rapid coronary balloon deflation times. Methods We performed a bench comparison of coronary balloon deflation times using 2 contrast agents with different viscosity (ioxaglate and iodixanol), 3 contrast dilutions, and 2 inflation syringe filling volumes. Ten identical pairs of coronary angioplasty balloons were used to conduct each comparison after balloon inflation to 12 atmospheres. Simultaneous deflations were performed under cineangiography. The time to full contrast extraction and the area of contrast remaining after 5-seconds of deflation (quantified by opaque pixel count) were compared between groups. Results The mean time to full contrast extraction during balloon deflation was 8.3±2.5-seconds for ioxaglate (lower viscosity) versus 10.1±2.9-seconds for iodixanol (higher viscosity) (17.4% decrease, P=0.005), with a 35.6% (P=0.004) reduction in contrast area at 5-seconds. Compared to 1:1 ioxaglate-saline mixture, 1:2 and 1:3 ioxaglate/saline mixes resulted in 26.7% (P<0.001) and 39.0% (P<0.001) reduction in mean balloon deflation time, respectively, but at the expense of decreased balloon opacity. Filling the inflation syringe with 5 versus 15-ml of contrast/saline solution was associated with 7.5% decrease in balloon deflation time (P=0.005), but no difference in contrast area at 5-seconds (P=0.749). Conclusions Use of a lower viscosity contrast agent and higher contrast dilution significantly reduced coronary balloon deflation times, whereas use of lower syringe filling volume had a modest effect. Rapid coronary balloon deflation could improve the safety of interventional procedures.

UR - http://www.scopus.com/inward/record.url?scp=84897982774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897982774&partnerID=8YFLogxK

U2 - 10.1111/joic.12097

DO - 10.1111/joic.12097

M3 - Article

C2 - 24450393

AN - SCOPUS:84897982774

VL - 27

SP - 177

EP - 181

JO - Journal of Interventional Cardiology

JF - Journal of Interventional Cardiology

SN - 0896-4327

IS - 2

ER -