Impact of donor-specific antibodies in reconstructive transplantation.

Angelo A. Leto Barone, Zhaoli Sun, Robert A. Montgomery, W. P.Andrew Lee, Gerald Brandacher

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

For many devastating injuries and tissue defects where conventional reconstruction is not possible, reconstructive transplantation such as hand and face transplantation has become a viable alternative. This novel approach allows for improved restoration of appearance, anatomy and function not feasible by other available treatment options. However, clinical management of these injuries prior to transplantation frequently requires multiple blood transfusion or skin grafts resulting in the formation of alloantibodies (anti-HLA IgG Abs) and a high degree of sensitization. The role of donor-specific antibodies (DSA) and mechanisms of antibody-mediated rejection (AMR) in reconstructive transplantation are still largely unknown. Thus there is an imminent need to develop a better understanding of the mechanisms related to DSA and AMR after reconstructive transplantation. In this review, we will define the role of DSA and mechanisms of AMR in reconstructive transplantation and compare them to established measures and treatment concepts in solid organ transplantation.

Original languageEnglish (US)
Pages (from-to)835-844
Number of pages10
JournalExpert review of clinical immunology
Volume9
Issue number9
StatePublished - Sep 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Leto Barone, A. A., Sun, Z., Montgomery, R. A., Lee, W. P. A., & Brandacher, G. (2013). Impact of donor-specific antibodies in reconstructive transplantation. Expert review of clinical immunology, 9(9), 835-844.