Impact of early valve surgery on outcome of staphylococcus aureus prosthetic valve infective endocarditis: Analysis in the international collaboration of endocarditis-prospective cohort study

Catherine Chirouze, François Alla, Vance G. Fowler, Daniel J. Sexton, G. Ralph Corey, Vivian H. Chu, Andrew Wang, Marie Line Erpelding, Emanuele Durante-Mangoni, Nuria Fernández-Hidalgo, Efthymia Giannitsioti, Margaret M. Hannan, Tatjana Lejko-Zupanc, José M. Miró, Patricia Muñoz, David R. Murdoch, Pierre Tattevin, Christophe Tribouilloy, Bruno Hoen, Liliana ClaraMarisa Sanchez, Francisco Nacinovich, Pablo Fernandez Oses, Ricardo Ronderos, Adriana Sucari, Jorge Thierer, José Casabé, Claudia Cortes, Javier Altclas, Silvia Kogan, Denis Spelman, Eugene Athan, Owen Harris, Karina Kennedy, Ren Tan, David Gordon, Lito Papanicolas, Damon Eisen, Leeanne Grigg, Alan Street, Tony Korman, Despina Kotsanas, Robyn Dever, Pam Konecny, Richard Lawrence, David Rees, Suzanne Ryan, Michael P. Feneley, John Harkness, Phillip Jones, Jeffrey Post, Porl Reinbott, Rainer Gattringer, Franz Wiesbauer, Adriana Ribas Andrade, Ana Cláudia Passos De Brito, Armenio Costa Guimarães, Max Grinberg, Alfredo José Mansur, Rinaldo Focaccia Siciliano, Tania Mara Varejao Strabelli, Marcelo Luiz Campos Vieira, Regina Aparecida De Medeiros Tranchesi, Marcelo Goulart Paiva, Claudio Querido Fortes, Auristela De Oliveira Ramos, Giovanna Ferraiuoli, Wilma Golebiovski, Cristiane Lamas, Marisa Santos, Clara Weksler, James A. Karlowsky, Yoav Keynan, Andrew M. Morris, Ethan Rubinstein, Sandra Braun Jones, Patricia Garcia, M. Cereceda, Alberto Fica, Rodrigo Montagna Mella, Bruno Barsic, Suzana Bukovski, Vladimir Krajinovic, Ana Pangercic, Igor Rudez, Josip Vincelj, Tomas Freiberger, Jiri Pol, Barbora Zaloudikova, Ashour Zainab, Amani El Kholy, Marwa Mishaal, Hussien Rizk, Neijla Aissa, Corentine Alauzet, Catherine Campagnac, Thanh Doco-Lecompte, Christine Selton-Suty, Jean Paul Casalta, Pierre Edouard Fournier, Gilbert Habib, Didier Raoult, Franck Thuny, François Delahaye, Armelle Delahaye, Francois Vandenesch, Erwan Donal, Pierre Yves Donnio, Christian Michelet, Matthieu Revest, Jérémie Violette, Florent Chevalier, Antoine Jeu, Dan M D Rusinaru, Claire Sorel, Yvette Bernard, Joel Leroy, Patrick Plesiat, Christoph Naber, Carl Neuerburg, Bahram Mazaheri, Sofia Athanasia, Ioannis Deliolanis, Helen Giamarellou, Thomas Tsaganos, Elena Mylona, Olga Paniara, Konstantinos Papanicolaou, John Pyros, Athanasios Skoutelis, Gautam Sharma, Johnson Francis, Lathi Nair, Vinod Thomas, Krishnan Venugopal, John Hurley, Dan Gilon, Sarah Israel, Maya Korem, Jacob Strahilevitz, Roberta Casillo, Susanna Cuccurullo, Giovanni Dialetto, Mattucci Irene, Enrico Ragone, Marie Françoise Tripodi, Riccardo Utili, Enrico Cecchi, Francesco De Rosa, Davide Forno, Massimo Imazio, Rita Trinchero, Alessandro Tebini, Paolo Grossi, Mariangela Lattanzio, Antonio Toniolo, Antonio Goglio, Annibale Raglio, Veronica Ravasio, Marco Rizzi, Fredy Suter, Giampiero Carosi, Silvia Magri, Liana Signorini, Tania Baban, Zeina Kanafani, Souha S. Kanj, Mohamad Yasmine, Imran Abidin, Syahidah Syed Tamin, Eduardo Rivera Martínez, Gabriel Israel Soto Nieto, Jan T M Van Der Meer, Stephen Chambers, David Holland, Arthur Morris, Nigel Raymond, Kerry Read, Stefan Dragulescu, Adina Ionac, Cristian Mornos, O. M. Butkevich, Natalia Chipigina, Ozerecky Kirill, Kulichenko Vadim, Tatiana Vinogradova, Jameela Edathodu, Magid Halim, Luh Nah Lum, Ru San Tan, Mateja Logar, Manica Mueller-Premru, Patrick Commerford, Anita Commerford, Eduan Deetlefs, Cass Hansa, Mpiko Ntsekhe, Manuel Almela, Yolanda Armero, Manuel Azqueta, Ximena Castañeda, Carlos Cervera, Ana Del Rio, Carlos Falces, Cristina Garcia-De-La-Maria, Guillermina Fita, Jose M. Gatell, Francesc Marco, Carlos A. Mestres, Asuncion Moreno, Salvador Ninot, Carlos Paré, Joan Pericas, Jose Ramirez, Irene Rovira, Marta Sitges, Ignasi Anguera, Bernat Font, Joan Raimon Guma, Javier Bermejo, Emilio Bouza, Miguel Angel Garcia Fernández, Victor Gonzalez-Ramallo, Mercedes Marín, Miguel Pedromingo, Jorge Roda, Marta Rodríguez-Créixems, Jorge Solis, Benito Almirante, Pilar Tornos, Arístides De Alarcón, Ricardo Parra, Eric Alestig, Magnus Johansson, Lars Olaison, Ulrika Snygg-Martin, Orathai Pachirat, Pimchitra Pachirat, Burabha Pussadhamma, Vichai Senthong, Anna Casey, Tom Elliott, Peter Lambert, Richard Watkin, Christina Eyton, John L. Klein, Suzanne Bradley, Carol Kauffman, Roger Bedimo, Anna Lisa Crowley, Pamela Douglas, Laura Drew, Thomas Holland, Tahaniyat Lalani, Daniel Mudrick, Zaniab Samad, Martin Stryjewski, Christopher W. Woods, Stamatios Lerakis, Robert Cantey, Lisa Steed, Dannah Wray, Stuart A. Dickerman, Hector Bonilla, Joseph Di Persio, Sara Jane Salstrom, John Baddley, Mukesh Patel, Gail Peterson, Amy Stancoven, Luis Afonso, Theresa Kulman, Donald Levine, Michael Rybak, Christopher H. Cabell, Khaula Baloch, Christy C. Dixon, Tina Harding, Marian Jones-Richmond, Paul Pappas, Lawrence P. Park, Thomas Redick, Judy Stafford, Kevin Anstrom, Arnold S. Bayer, A. W. Karchmer, David T. Durack, Susannah Eykyn, Phillipe Moreillon

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Background. The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. Methods. Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use. Results. EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15). Conclusions. In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.

Original languageEnglish (US)
Pages (from-to)741-749
Number of pages9
JournalClinical Infectious Diseases
Volume60
Issue number5
DOIs
Publication statusPublished - 2015

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Keywords

  • 1-year mortality
  • Endocarditis
  • Prosthetic valve
  • Surgery

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

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