Abstract
Background. The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. Methods. Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use. Results. EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15). Conclusions. In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 741-749 |
| Number of pages | 9 |
| Journal | Clinical Infectious Diseases |
| Volume | 60 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 1 2015 |
Keywords
- 1-year mortality
- Endocarditis
- Prosthetic valve
- Surgery
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
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In: Clinical Infectious Diseases, Vol. 60, No. 5, 01.03.2015, p. 741-749.
Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Impact of early valve surgery on outcome of staphylococcus aureus prosthetic valve infective endocarditis
T2 - Analysis in the international collaboration of endocarditis-prospective cohort study
AU - Chirouze, Catherine
AU - Alla, François
AU - Fowler, Vance G.
AU - Sexton, Daniel J.
AU - Corey, G. Ralph
AU - Chu, Vivian H.
AU - Wang, Andrew
AU - Erpelding, Marie Line
AU - Durante-Mangoni, Emanuele
AU - Fernández-Hidalgo, Nuria
AU - Giannitsioti, Efthymia
AU - Hannan, Margaret M.
AU - Lejko-Zupanc, Tatjana
AU - Miró, José M.
AU - Muñoz, Patricia
AU - Murdoch, David R.
AU - Tattevin, Pierre
AU - Tribouilloy, Christophe
AU - Hoen, Bruno
AU - Clara, Liliana
AU - Sanchez, Marisa
AU - Nacinovich, Francisco
AU - Oses, Pablo Fernandez
AU - Ronderos, Ricardo
AU - Sucari, Adriana
AU - Thierer, Jorge
AU - Casabé, José
AU - Cortes, Claudia
AU - Altclas, Javier
AU - Kogan, Silvia
AU - Spelman, Denis
AU - Athan, Eugene
AU - Harris, Owen
AU - Kennedy, Karina
AU - Tan, Ren
AU - Gordon, David
AU - Papanicolas, Lito
AU - Eisen, Damon
AU - Grigg, Leeanne
AU - Street, Alan
AU - Korman, Tony
AU - Kotsanas, Despina
AU - Dever, Robyn
AU - Konecny, Pam
AU - Lawrence, Richard
AU - Rees, David
AU - Ryan, Suzanne
AU - Feneley, Michael P.
AU - Harkness, John
AU - Jones, Phillip
AU - Post, Jeffrey
AU - Reinbott, Porl
AU - Gattringer, Rainer
AU - Wiesbauer, Franz
AU - Andrade, Adriana Ribas
AU - De Brito, Ana Cláudia Passos
AU - Guimarães, Armenio Costa
AU - Grinberg, Max
AU - Mansur, Alfredo José
AU - Siciliano, Rinaldo Focaccia
AU - Strabelli, Tania Mara Varejao
AU - Vieira, Marcelo Luiz Campos
AU - De Medeiros Tranchesi, Regina Aparecida
AU - Paiva, Marcelo Goulart
AU - Fortes, Claudio Querido
AU - De Oliveira Ramos, Auristela
AU - Ferraiuoli, Giovanna
AU - Golebiovski, Wilma
AU - Lamas, Cristiane
AU - Santos, Marisa
AU - Weksler, Clara
AU - Karlowsky, James A.
AU - Keynan, Yoav
AU - Morris, Andrew M.
AU - Rubinstein, Ethan
AU - Jones, Sandra Braun
AU - Garcia, Patricia
AU - Cereceda, M.
AU - Fica, Alberto
AU - Mella, Rodrigo Montagna
AU - Barsic, Bruno
AU - Bukovski, Suzana
AU - Krajinovic, Vladimir
AU - Pangercic, Ana
AU - Rudez, Igor
AU - Vincelj, Josip
AU - Freiberger, Tomas
AU - Pol, Jiri
AU - Zaloudikova, Barbora
AU - Zainab, Ashour
AU - El Kholy, Amani
AU - Mishaal, Marwa
AU - Rizk, Hussien
AU - Aissa, Neijla
AU - Alauzet, Corentine
AU - Campagnac, Catherine
AU - Doco-Lecompte, Thanh
AU - Selton-Suty, Christine
AU - Casalta, Jean Paul
AU - Fournier, Pierre Edouard
AU - Habib, Gilbert
AU - Raoult, Didier
AU - Thuny, Franck
AU - Delahaye, François
AU - Delahaye, Armelle
AU - Vandenesch, Francois
AU - Donal, Erwan
AU - Donnio, Pierre Yves
AU - Michelet, Christian
AU - Revest, Matthieu
AU - Violette, Jérémie
AU - Chevalier, Florent
AU - Jeu, Antoine
AU - Rusinaru, Dan M D
AU - Sorel, Claire
AU - Bernard, Yvette
AU - Leroy, Joel
AU - Plesiat, Patrick
AU - Naber, Christoph
AU - Neuerburg, Carl
AU - Mazaheri, Bahram
AU - Athanasia, Sofia
AU - Deliolanis, Ioannis
AU - Giamarellou, Helen
AU - Tsaganos, Thomas
AU - Mylona, Elena
AU - Paniara, Olga
AU - Papanicolaou, Konstantinos
AU - Pyros, John
AU - Skoutelis, Athanasios
AU - Sharma, Gautam
AU - Francis, Johnson
AU - Nair, Lathi
AU - Thomas, Vinod
AU - Venugopal, Krishnan
AU - Hurley, John
AU - Gilon, Dan
AU - Israel, Sarah
AU - Korem, Maya
AU - Strahilevitz, Jacob
AU - Casillo, Roberta
AU - Cuccurullo, Susanna
AU - Dialetto, Giovanni
AU - Irene, Mattucci
AU - Ragone, Enrico
AU - Tripodi, Marie Françoise
AU - Utili, Riccardo
AU - Cecchi, Enrico
AU - De Rosa, Francesco
AU - Forno, Davide
AU - Imazio, Massimo
AU - Trinchero, Rita
AU - Tebini, Alessandro
AU - Grossi, Paolo
AU - Lattanzio, Mariangela
AU - Toniolo, Antonio
AU - Goglio, Antonio
AU - Raglio, Annibale
AU - Ravasio, Veronica
AU - Rizzi, Marco
AU - Suter, Fredy
AU - Carosi, Giampiero
AU - Magri, Silvia
AU - Signorini, Liana
AU - Baban, Tania
AU - Kanafani, Zeina
AU - Kanj, Souha S.
AU - Yasmine, Mohamad
AU - Abidin, Imran
AU - Tamin, Syahidah Syed
AU - Martínez, Eduardo Rivera
AU - Nieto, Gabriel Israel Soto
AU - Van Der Meer, Jan T M
AU - Chambers, Stephen
AU - Holland, David
AU - Morris, Arthur
AU - Raymond, Nigel
AU - Read, Kerry
AU - Dragulescu, Stefan
AU - Ionac, Adina
AU - Mornos, Cristian
AU - Butkevich, O. M.
AU - Chipigina, Natalia
AU - Kirill, Ozerecky
AU - Vadim, Kulichenko
AU - Vinogradova, Tatiana
AU - Edathodu, Jameela
AU - Halim, Magid
AU - Lum, Luh Nah
AU - Tan, Ru San
AU - Logar, Mateja
AU - Mueller-Premru, Manica
AU - Commerford, Patrick
AU - Commerford, Anita
AU - Deetlefs, Eduan
AU - Hansa, Cass
AU - Ntsekhe, Mpiko
AU - Almela, Manuel
AU - Armero, Yolanda
AU - Azqueta, Manuel
AU - Castañeda, Ximena
AU - Cervera, Carlos
AU - Del Rio, Ana
AU - Falces, Carlos
AU - Garcia-De-La-Maria, Cristina
AU - Fita, Guillermina
AU - Gatell, Jose M.
AU - Marco, Francesc
AU - Mestres, Carlos A.
AU - Moreno, Asuncion
AU - Ninot, Salvador
AU - Paré, Carlos
AU - Pericas, Joan
AU - Ramirez, Jose
AU - Rovira, Irene
AU - Sitges, Marta
AU - Anguera, Ignasi
AU - Font, Bernat
AU - Guma, Joan Raimon
AU - Bermejo, Javier
AU - Bouza, Emilio
AU - Fernández, Miguel Angel Garcia
AU - Gonzalez-Ramallo, Victor
AU - Marín, Mercedes
AU - Pedromingo, Miguel
AU - Roda, Jorge
AU - Rodríguez-Créixems, Marta
AU - Solis, Jorge
AU - Almirante, Benito
AU - Tornos, Pilar
AU - De Alarcón, Arístides
AU - Parra, Ricardo
AU - Alestig, Eric
AU - Johansson, Magnus
AU - Olaison, Lars
AU - Snygg-Martin, Ulrika
AU - Pachirat, Orathai
AU - Pachirat, Pimchitra
AU - Pussadhamma, Burabha
AU - Senthong, Vichai
AU - Casey, Anna
AU - Elliott, Tom
AU - Lambert, Peter
AU - Watkin, Richard
AU - Eyton, Christina
AU - Klein, John L.
AU - Bradley, Suzanne
AU - Kauffman, Carol
AU - Bedimo, Roger
AU - Crowley, Anna Lisa
AU - Douglas, Pamela
AU - Drew, Laura
AU - Holland, Thomas
AU - Lalani, Tahaniyat
AU - Mudrick, Daniel
AU - Samad, Zaniab
AU - Stryjewski, Martin
AU - Woods, Christopher W.
AU - Lerakis, Stamatios
AU - Cantey, Robert
AU - Steed, Lisa
AU - Wray, Dannah
AU - Dickerman, Stuart A.
AU - Bonilla, Hector
AU - Di Persio, Joseph
AU - Salstrom, Sara Jane
AU - Baddley, John
AU - Patel, Mukesh
AU - Peterson, Gail
AU - Stancoven, Amy
AU - Afonso, Luis
AU - Kulman, Theresa
AU - Levine, Donald
AU - Rybak, Michael
AU - Cabell, Christopher H.
AU - Baloch, Khaula
AU - Dixon, Christy C.
AU - Harding, Tina
AU - Jones-Richmond, Marian
AU - Pappas, Paul
AU - Park, Lawrence P.
AU - Redick, Thomas
AU - Stafford, Judy
AU - Anstrom, Kevin
AU - Bayer, Arnold S.
AU - Karchmer, A. W.
AU - Durack, David T.
AU - Eykyn, Susannah
AU - Moreillon, Phillipe
N1 - Publisher Copyright: © The Author 2014.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Background. The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. Methods. Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use. Results. EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15). Conclusions. In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.
AB - Background. The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. Methods. Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use. Results. EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15). Conclusions. In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.
KW - 1-year mortality
KW - Endocarditis
KW - Prosthetic valve
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=84929147308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929147308&partnerID=8YFLogxK
U2 - 10.1093/cid/ciu871
DO - 10.1093/cid/ciu871
M3 - Article
C2 - 25389255
AN - SCOPUS:84929147308
SN - 1058-4838
VL - 60
SP - 741
EP - 749
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -