Impact of HPV-Related Head and Neck Cancer in Clinical Trials: Opportunity to Translate Scientific Insight into Personalized Care

Christine H. Chung, David L. Schwartz

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Patients with human papillomavirus (HPV)-positive squamous cell carcinoma of the oropharynx (SCCOP) enjoy better treatment outcomes than patients suffering from HPV-negative head and neck cancer. To maintain the integrity and utility of future clinical trials, HPV-positive SCCOP must be studied as a distinct entity. The discovery of HPV-positive disease has (1) convoluted comparison of current phase II trial data to historical controls, (2) made formal stratification for HPV infection status an imperative for future phase III trial design, and (3) drawn focus toward opportunities for personalization of treatment intensity. This review discusses these research issues.

Original languageEnglish (US)
Pages (from-to)795-806
Number of pages12
JournalOtolaryngologic Clinics of North America
Volume45
Issue number4
DOIs
StatePublished - Aug 1 2012

Keywords

  • Biomarkers
  • Chemotherapy
  • Clinical trials
  • Head and neck cancer
  • Human papillomavirus
  • Radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

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