Impact of medical comorbidity in biomarker discovery for major depressive disorder

Andrew Czysz

Research output: Contribution to journalArticlepeer-review


The interaction between major depressive disorder (MDD) and other medical conditions is increasingly recognized as an important factor for clinical management and for biomarker development. Many common medical conditions have a bidirectional epidemiologic relationship with MDD that may have roots in shared pathophysiologic, environmental, and psychosocial factors. Furthermore, depression is increasingly recognized as a systemic disease. Understanding this relationship is challenging because of the immense variability between patients with MDD and also within other medical disorders themselves. This includes not only specific symptoms, but also disease severity, duration, disability, and treatment resistance.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalPsychiatric Annals
Issue number6
StatePublished - 2020

ASJC Scopus subject areas

  • Psychiatry and Mental health


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