Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention

Christopher R. deFilippi, James A de Lemos, Anne B. Newman, Jack M. Guralnik, Robert H. Christenson, Marco Pahor, Timothy Church, Mark Espeland, Stephen B. Krithevsky, Randall Stafford, Stephen L. Seliger

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. Methods Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control. High-sensitive cTnT was measured at baseline and 1 year in the 307 of 424 subjects who had available stored serum. Changes in hs-cTnT within 1 year were compared between PA and control groups, as were differences in the proportion of subjects with a significant rise in hs-cTnT (prospectively defined as a>50% increase at follow-up from baseline). Moderate to vigorous PA in kcal/wk was estimated with the CHAMPS questionnaire. Results Baseline hs-cTnT levels and PA kcal/wk were similar for both groups. Activity kcal/wk increased in the PA, but not in the control group at 1 year. The median increase in hs-cTnT level from baseline was >3 times larger in the control (0.73 ng/L, interquartile range −0.64 to 2.59) vs the PA group (0.19ng/L, interquartile range −1.10 to 1.93) (P=.02). The proportion with a>50% increase in hs-cTnT was larger in the control group than in the PA group (9.3% vs 5.1%), but this difference was not statistically significant (P=.16). Conclusions Initiation of moderate PA in sedentary older adults may favorably modify subclinical myocardial injury.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalAmerican Heart Journal
Volume179
DOIs
StatePublished - Sep 1 2016

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Troponin T
Biomarkers
Wounds and Injuries
Control Groups
Physical Education and Training
Health Education
Cardiac Myocytes
Muscle Cells
Observational Studies
Cell Death
Randomized Controlled Trials
Animal Models
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury : Results from a randomized pilot study of exercise intervention. / deFilippi, Christopher R.; de Lemos, James A; Newman, Anne B.; Guralnik, Jack M.; Christenson, Robert H.; Pahor, Marco; Church, Timothy; Espeland, Mark; Krithevsky, Stephen B.; Stafford, Randall; Seliger, Stephen L.

In: American Heart Journal, Vol. 179, 01.09.2016, p. 151-156.

Research output: Contribution to journalArticle

deFilippi, CR, de Lemos, JA, Newman, AB, Guralnik, JM, Christenson, RH, Pahor, M, Church, T, Espeland, M, Krithevsky, SB, Stafford, R & Seliger, SL 2016, 'Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention', American Heart Journal, vol. 179, pp. 151-156. https://doi.org/10.1016/j.ahj.2016.07.001
deFilippi, Christopher R. ; de Lemos, James A ; Newman, Anne B. ; Guralnik, Jack M. ; Christenson, Robert H. ; Pahor, Marco ; Church, Timothy ; Espeland, Mark ; Krithevsky, Stephen B. ; Stafford, Randall ; Seliger, Stephen L. / Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury : Results from a randomized pilot study of exercise intervention. In: American Heart Journal. 2016 ; Vol. 179. pp. 151-156.
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abstract = "In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. Methods Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control. High-sensitive cTnT was measured at baseline and 1 year in the 307 of 424 subjects who had available stored serum. Changes in hs-cTnT within 1 year were compared between PA and control groups, as were differences in the proportion of subjects with a significant rise in hs-cTnT (prospectively defined as a>50{\%} increase at follow-up from baseline). Moderate to vigorous PA in kcal/wk was estimated with the CHAMPS questionnaire. Results Baseline hs-cTnT levels and PA kcal/wk were similar for both groups. Activity kcal/wk increased in the PA, but not in the control group at 1 year. The median increase in hs-cTnT level from baseline was >3 times larger in the control (0.73 ng/L, interquartile range −0.64 to 2.59) vs the PA group (0.19ng/L, interquartile range −1.10 to 1.93) (P=.02). The proportion with a>50{\%} increase in hs-cTnT was larger in the control group than in the PA group (9.3{\%} vs 5.1{\%}), but this difference was not statistically significant (P=.16). Conclusions Initiation of moderate PA in sedentary older adults may favorably modify subclinical myocardial injury.",
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T2 - Results from a randomized pilot study of exercise intervention

AU - deFilippi, Christopher R.

AU - de Lemos, James A

AU - Newman, Anne B.

AU - Guralnik, Jack M.

AU - Christenson, Robert H.

AU - Pahor, Marco

AU - Church, Timothy

AU - Espeland, Mark

AU - Krithevsky, Stephen B.

AU - Stafford, Randall

AU - Seliger, Stephen L.

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N2 - In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. Methods Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control. High-sensitive cTnT was measured at baseline and 1 year in the 307 of 424 subjects who had available stored serum. Changes in hs-cTnT within 1 year were compared between PA and control groups, as were differences in the proportion of subjects with a significant rise in hs-cTnT (prospectively defined as a>50% increase at follow-up from baseline). Moderate to vigorous PA in kcal/wk was estimated with the CHAMPS questionnaire. Results Baseline hs-cTnT levels and PA kcal/wk were similar for both groups. Activity kcal/wk increased in the PA, but not in the control group at 1 year. The median increase in hs-cTnT level from baseline was >3 times larger in the control (0.73 ng/L, interquartile range −0.64 to 2.59) vs the PA group (0.19ng/L, interquartile range −1.10 to 1.93) (P=.02). The proportion with a>50% increase in hs-cTnT was larger in the control group than in the PA group (9.3% vs 5.1%), but this difference was not statistically significant (P=.16). Conclusions Initiation of moderate PA in sedentary older adults may favorably modify subclinical myocardial injury.

AB - In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. Methods Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control. High-sensitive cTnT was measured at baseline and 1 year in the 307 of 424 subjects who had available stored serum. Changes in hs-cTnT within 1 year were compared between PA and control groups, as were differences in the proportion of subjects with a significant rise in hs-cTnT (prospectively defined as a>50% increase at follow-up from baseline). Moderate to vigorous PA in kcal/wk was estimated with the CHAMPS questionnaire. Results Baseline hs-cTnT levels and PA kcal/wk were similar for both groups. Activity kcal/wk increased in the PA, but not in the control group at 1 year. The median increase in hs-cTnT level from baseline was >3 times larger in the control (0.73 ng/L, interquartile range −0.64 to 2.59) vs the PA group (0.19ng/L, interquartile range −1.10 to 1.93) (P=.02). The proportion with a>50% increase in hs-cTnT was larger in the control group than in the PA group (9.3% vs 5.1%), but this difference was not statistically significant (P=.16). Conclusions Initiation of moderate PA in sedentary older adults may favorably modify subclinical myocardial injury.

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