Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention

Christopher R. deFilippi, James A de Lemos, Anne B. Newman, Jack M. Guralnik, Robert H. Christenson, Marco Pahor, Timothy Church, Mark Espeland, Stephen B. Krithevsky, Randall Stafford, Stephen L. Seliger

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. Methods Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control. High-sensitive cTnT was measured at baseline and 1 year in the 307 of 424 subjects who had available stored serum. Changes in hs-cTnT within 1 year were compared between PA and control groups, as were differences in the proportion of subjects with a significant rise in hs-cTnT (prospectively defined as a>50% increase at follow-up from baseline). Moderate to vigorous PA in kcal/wk was estimated with the CHAMPS questionnaire. Results Baseline hs-cTnT levels and PA kcal/wk were similar for both groups. Activity kcal/wk increased in the PA, but not in the control group at 1 year. The median increase in hs-cTnT level from baseline was >3 times larger in the control (0.73 ng/L, interquartile range −0.64 to 2.59) vs the PA group (0.19ng/L, interquartile range −1.10 to 1.93) (P=.02). The proportion with a>50% increase in hs-cTnT was larger in the control group than in the PA group (9.3% vs 5.1%), but this difference was not statistically significant (P=.16). Conclusions Initiation of moderate PA in sedentary older adults may favorably modify subclinical myocardial injury.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalAmerican heart journal
Volume179
DOIs
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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