Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging

Junichi Tokuda, Hatsuho Mamata, Ritu R. Gill, Nobuhiko Hata, Ron Kikinis, Robert F. Padera, Robert E. Lenkinski, David J. Sugarbaker, Hiroto Hatabu

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Purpose: To investigates the impact of nonrigid motion correction on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free-breathing dynamic contrast-enhanced MRI (DCE-MRI) precludes obtaining reliable time-intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization. Materials and Methods: Single-slice 2D DCE-MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B-spline image registration. Pixelwise pharmacokinetic parameters Ktrans, υe, and κep were estimated from both original and motion-corrected DCE-MRI by fitting the two-compartment pharmacokinetic model to the time-intensity curve obtained in each pixel. The "goodness-of-fit" was tested with χ2- test in pixel-by-pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion-corrected DCE-MRI. In addition, the parameters obtained from benign and malignant SPNs were compared. Results: The percentage of reliable pixels in the motion-corrected DCE-MRI was significantly larger than the original DCE-MRI (P = 4 × 10-7). Both Ktrans and κep derived from the motion-corrected DCE-MRI showed significant differences between benign and malignant SPNs (P = 0.024, 0.015). Conclusion: The study demonstrated the impact of non-rigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in SPNs.

Original languageEnglish (US)
Pages (from-to)968-973
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume33
Issue number4
DOIs
StatePublished - Apr 1 2011

Keywords

  • Dynamic contrast-enhanced MRI
  • Motion correction
  • Nonrigid image registration
  • Pharmacokinetic analysis
  • Solitary pulmonary nodule

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Tokuda, J., Mamata, H., Gill, R. R., Hata, N., Kikinis, R., Padera, R. F., Lenkinski, R. E., Sugarbaker, D. J., & Hatabu, H. (2011). Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging. Journal of Magnetic Resonance Imaging, 33(4), 968-973. https://doi.org/10.1002/jmri.22490