Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging

Junichi Tokuda, Hatsuho Mamata, Ritu R. Gill, Nobuhiko Hata, Ron Kikinis, Robert F. Padera, Robert E. Lenkinski, David J. Sugarbaker, Hiroto Hatabu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: To investigates the impact of nonrigid motion correction on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free-breathing dynamic contrast-enhanced MRI (DCE-MRI) precludes obtaining reliable time-intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization. Materials and Methods: Single-slice 2D DCE-MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B-spline image registration. Pixelwise pharmacokinetic parameters Ktrans, υe, and κep were estimated from both original and motion-corrected DCE-MRI by fitting the two-compartment pharmacokinetic model to the time-intensity curve obtained in each pixel. The "goodness-of-fit" was tested with χ2- test in pixel-by-pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion-corrected DCE-MRI. In addition, the parameters obtained from benign and malignant SPNs were compared. Results: The percentage of reliable pixels in the motion-corrected DCE-MRI was significantly larger than the original DCE-MRI (P = 4 × 10-7). Both Ktrans and κep derived from the motion-corrected DCE-MRI showed significant differences between benign and malignant SPNs (P = 0.024, 0.015). Conclusion: The study demonstrated the impact of non-rigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in SPNs.

Original languageEnglish (US)
Pages (from-to)968-973
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume33
Issue number4
DOIs
StatePublished - Apr 2011

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Solitary Pulmonary Nodule
Respiration
Pharmacokinetics
Lung

Keywords

  • Dynamic contrast-enhanced MRI
  • Motion correction
  • Nonrigid image registration
  • Pharmacokinetic analysis
  • Solitary pulmonary nodule

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging. / Tokuda, Junichi; Mamata, Hatsuho; Gill, Ritu R.; Hata, Nobuhiko; Kikinis, Ron; Padera, Robert F.; Lenkinski, Robert E.; Sugarbaker, David J.; Hatabu, Hiroto.

In: Journal of Magnetic Resonance Imaging, Vol. 33, No. 4, 04.2011, p. 968-973.

Research output: Contribution to journalArticle

Tokuda, Junichi ; Mamata, Hatsuho ; Gill, Ritu R. ; Hata, Nobuhiko ; Kikinis, Ron ; Padera, Robert F. ; Lenkinski, Robert E. ; Sugarbaker, David J. ; Hatabu, Hiroto. / Impact of nonrigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing pulmonary dynamic contrast-enhanced MR imaging. In: Journal of Magnetic Resonance Imaging. 2011 ; Vol. 33, No. 4. pp. 968-973.
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abstract = "Purpose: To investigates the impact of nonrigid motion correction on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free-breathing dynamic contrast-enhanced MRI (DCE-MRI) precludes obtaining reliable time-intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization. Materials and Methods: Single-slice 2D DCE-MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B-spline image registration. Pixelwise pharmacokinetic parameters Ktrans, υe, and κep were estimated from both original and motion-corrected DCE-MRI by fitting the two-compartment pharmacokinetic model to the time-intensity curve obtained in each pixel. The {"}goodness-of-fit{"} was tested with χ2- test in pixel-by-pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion-corrected DCE-MRI. In addition, the parameters obtained from benign and malignant SPNs were compared. Results: The percentage of reliable pixels in the motion-corrected DCE-MRI was significantly larger than the original DCE-MRI (P = 4 × 10-7). Both Ktrans and κep derived from the motion-corrected DCE-MRI showed significant differences between benign and malignant SPNs (P = 0.024, 0.015). Conclusion: The study demonstrated the impact of non-rigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in SPNs.",
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author = "Junichi Tokuda and Hatsuho Mamata and Gill, {Ritu R.} and Nobuhiko Hata and Ron Kikinis and Padera, {Robert F.} and Lenkinski, {Robert E.} and Sugarbaker, {David J.} and Hiroto Hatabu",
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AU - Tokuda, Junichi

AU - Mamata, Hatsuho

AU - Gill, Ritu R.

AU - Hata, Nobuhiko

AU - Kikinis, Ron

AU - Padera, Robert F.

AU - Lenkinski, Robert E.

AU - Sugarbaker, David J.

AU - Hatabu, Hiroto

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N2 - Purpose: To investigates the impact of nonrigid motion correction on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free-breathing dynamic contrast-enhanced MRI (DCE-MRI) precludes obtaining reliable time-intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization. Materials and Methods: Single-slice 2D DCE-MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B-spline image registration. Pixelwise pharmacokinetic parameters Ktrans, υe, and κep were estimated from both original and motion-corrected DCE-MRI by fitting the two-compartment pharmacokinetic model to the time-intensity curve obtained in each pixel. The "goodness-of-fit" was tested with χ2- test in pixel-by-pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion-corrected DCE-MRI. In addition, the parameters obtained from benign and malignant SPNs were compared. Results: The percentage of reliable pixels in the motion-corrected DCE-MRI was significantly larger than the original DCE-MRI (P = 4 × 10-7). Both Ktrans and κep derived from the motion-corrected DCE-MRI showed significant differences between benign and malignant SPNs (P = 0.024, 0.015). Conclusion: The study demonstrated the impact of non-rigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in SPNs.

AB - Purpose: To investigates the impact of nonrigid motion correction on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free-breathing dynamic contrast-enhanced MRI (DCE-MRI) precludes obtaining reliable time-intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization. Materials and Methods: Single-slice 2D DCE-MRI was obtained in 15 patients. Misalignments of SPNs were corrected using nonrigid B-spline image registration. Pixelwise pharmacokinetic parameters Ktrans, υe, and κep were estimated from both original and motion-corrected DCE-MRI by fitting the two-compartment pharmacokinetic model to the time-intensity curve obtained in each pixel. The "goodness-of-fit" was tested with χ2- test in pixel-by-pixel basis to evaluate the reliability of the parameters. The percentages of reliable pixels within the SPNs were compared between the original and motion-corrected DCE-MRI. In addition, the parameters obtained from benign and malignant SPNs were compared. Results: The percentage of reliable pixels in the motion-corrected DCE-MRI was significantly larger than the original DCE-MRI (P = 4 × 10-7). Both Ktrans and κep derived from the motion-corrected DCE-MRI showed significant differences between benign and malignant SPNs (P = 0.024, 0.015). Conclusion: The study demonstrated the impact of non-rigid motion correction technique on pixel-wise pharmacokinetic analysis of free-breathing DCE-MRI in SPNs.

KW - Dynamic contrast-enhanced MRI

KW - Motion correction

KW - Nonrigid image registration

KW - Pharmacokinetic analysis

KW - Solitary pulmonary nodule

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