Impact of Obesity on Cardiovascular Disease

Kerstyn C. Zalesin, Barry A. Franklin, Wendy M. Miller, Eric D. Peterson, Peter A. McCullough

Research output: Contribution to journalReview articlepeer-review

148 Scopus citations


The epidemiology of cardiovacular disease risk factors is changing rapidly with the obesity pandemic. Obesity is independently associated with the risks for coronary heart disease, atrial fibrillation, and heart failure. Intra-abdominal obesity is also unique as a cardiovascular risk state in that it contributes to or directly causes most other modifiable risk factors, namely, hypertension, dysmetabolic syndrome, and type 2 diabetes mellitus. Obesity can also exacerbate cardiovascular disease through a variety of mechanisms including systemic inflammation, hypercoagulability, and activation of the sympathetic and reninangiotensin systems. Thus, weight reduction is a key strategy for simultaneous improvement in global cardiovascular risk, with anticipated improvements in survival and quality of life.

Original languageEnglish (US)
Pages (from-to)919-937
Number of pages19
JournalMedical Clinics of North America
Issue number5
StatePublished - Sep 2011
Externally publishedYes


  • Body mass index
  • Cardiac risk factors
  • Cardiovascular disease
  • Coronary heart disease
  • Obesity
  • Visceral obesity

ASJC Scopus subject areas

  • Medicine(all)


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