TY - JOUR
T1 - Impact of Obesity on Cardiovascular Disease
AU - Zalesin, Kerstyn C.
AU - Franklin, Barry A.
AU - Miller, Wendy M.
AU - Peterson, Eric D.
AU - McCullough, Peter A.
PY - 2011/9
Y1 - 2011/9
N2 - The epidemiology of cardiovacular disease risk factors is changing rapidly with the obesity pandemic. Obesity is independently associated with the risks for coronary heart disease, atrial fibrillation, and heart failure. Intra-abdominal obesity is also unique as a cardiovascular risk state in that it contributes to or directly causes most other modifiable risk factors, namely, hypertension, dysmetabolic syndrome, and type 2 diabetes mellitus. Obesity can also exacerbate cardiovascular disease through a variety of mechanisms including systemic inflammation, hypercoagulability, and activation of the sympathetic and reninangiotensin systems. Thus, weight reduction is a key strategy for simultaneous improvement in global cardiovascular risk, with anticipated improvements in survival and quality of life.
AB - The epidemiology of cardiovacular disease risk factors is changing rapidly with the obesity pandemic. Obesity is independently associated with the risks for coronary heart disease, atrial fibrillation, and heart failure. Intra-abdominal obesity is also unique as a cardiovascular risk state in that it contributes to or directly causes most other modifiable risk factors, namely, hypertension, dysmetabolic syndrome, and type 2 diabetes mellitus. Obesity can also exacerbate cardiovascular disease through a variety of mechanisms including systemic inflammation, hypercoagulability, and activation of the sympathetic and reninangiotensin systems. Thus, weight reduction is a key strategy for simultaneous improvement in global cardiovascular risk, with anticipated improvements in survival and quality of life.
KW - Body mass index
KW - Cardiac risk factors
KW - Cardiovascular disease
KW - Coronary heart disease
KW - Obesity
KW - Visceral obesity
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U2 - 10.1016/j.mcna.2011.06.005
DO - 10.1016/j.mcna.2011.06.005
M3 - Review article
C2 - 21855700
AN - SCOPUS:80051809646
VL - 95
SP - 919
EP - 937
JO - Medical Clinics of North America
JF - Medical Clinics of North America
SN - 0025-7125
IS - 5
ER -