Impact of Obesity on Cardiovascular Disease

Kerstyn C. Zalesin, Barry A. Franklin, Wendy M. Miller, Eric D. Peterson, Peter A. McCullough

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations


The epidemiology of cardiovacular disease risk factors is changing rapidly with the obesity pandemic. Obesity is independently associated with the risks for coronary heart disease, atrial fibrillation, and heart failure. Intra-abdominal obesity is also unique as a cardiovascular risk state in that it contributes to or directly causes most other modifiable risk factors, namely, hypertension, dysmetabolic syndrome, and type 2 diabetes mellitus. Obesity can also exacerbate cardiovascular disease through a variety of mechanisms including systemic inflammation, hypercoagulability, and activation of the sympathetic and renin-angiotensin systems. Thus, weight reduction is a key strategy for simultaneous improvement in global cardiovascular risk, with anticipated improvements in survival and quality of life.

Original languageEnglish (US)
Pages (from-to)663-684
Number of pages22
JournalEndocrinology and Metabolism Clinics of North America
Issue number3
StatePublished - Sep 2008
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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