Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy

Seshadri Balaji; Michael P. DiLorenzo; Frank A. Fish; Susan P. Etheridge; Peter F. Aziz; Mark W. Russell; Svjetlana Tisma; Andreas Pflaumer; Narayanswami Sreeram; Peter Kubus; Ian H. Law; Michal J. Kantoch; Naomi J. Kertesz; Margaret Strieper; Christopher C. Erickson; Jeremy P. Moore; Stephanie J. Nakano; Harinder R. Singh; Philip Chang; Mitchell Cohen; Anne Fournier; Maria V. Ilina; Richard T. Smith; Frank Zimmerman; Michaela Horndasch; Walter Li; Anjan Batra; Leonardo Liberman; Robert Hamilton; Christopher M. Janson; Shubhayan Sanatani; Ilana Zeltser; George McDaniel; Andrew D. Blaufox; Jason M. Garnreiter; Hannah Katcoff; Maully Shah

doi:10.1007/s00246-019-02145-9

Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy

Seshadri Balaji, Michael P. DiLorenzo, Frank A. Fish, Susan P. Etheridge, Peter F. Aziz, Mark W. Russell, Svjetlana Tisma, Andreas Pflaumer, Narayanswami Sreeram, Peter Kubus, Ian H. Law, Michal J. Kantoch, Naomi J. Kertesz, Margaret Strieper, Christopher C. Erickson, Jeremy P. Moore, Stephanie J. Nakano, Harinder R. Singh, Philip Chang, Mitchell CohenAnne Fournier, Maria V. Ilina, Richard T. Smith, Frank Zimmerman, Michaela Horndasch, Walter Li, Anjan Batra, Leonardo Liberman, Robert Hamilton, Christopher M. Janson, Shubhayan Sanatani, Ilana Zeltser, George McDaniel, Andrew D. Blaufox, Jason M. Garnreiter, Hannah Katcoff, Maully Shah

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients’ weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18–50, mean 29.1) was present in 140 children aged 2–19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.

Original language	English (US)
Pages (from-to)	1253-1257
Number of pages	5
Journal	Pediatric Cardiology
Volume	40
Issue number	6
DOIs	https://doi.org/10.1007/s00246-019-02145-9
State	Published - Aug 15 2019

Keywords

Defibrillator
Hypertrophic cardiomyopathy
Obesity
Sudden death

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

Access to Document

10.1007/s00246-019-02145-9

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Balaji, S., DiLorenzo, M. P., Fish, F. A., Etheridge, S. P., Aziz, P. F., Russell, M. W., Tisma, S., Pflaumer, A., Sreeram, N., Kubus, P., Law, I. H., Kantoch, M. J., Kertesz, N. J., Strieper, M., Erickson, C. C., Moore, J. P., Nakano, S. J., Singh, H. R., Chang, P., ... Shah, M. (2019). Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy. Pediatric Cardiology, 40(6), 1253-1257. https://doi.org/10.1007/s00246-019-02145-9

Balaji, S, DiLorenzo, MP, Fish, FA, Etheridge, SP, Aziz, PF, Russell, MW, Tisma, S, Pflaumer, A, Sreeram, N, Kubus, P, Law, IH, Kantoch, MJ, Kertesz, NJ, Strieper, M, Erickson, CC, Moore, JP, Nakano, SJ, Singh, HR, Chang, P, Cohen, M, Fournier, A, Ilina, MV, Smith, RT, Zimmerman, F, Horndasch, M, Li, W, Batra, A, Liberman, L, Hamilton, R, Janson, CM, Sanatani, S, Zeltser, I, McDaniel, G, Blaufox, AD, Garnreiter, JM, Katcoff, H & Shah, M 2019, 'Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy', Pediatric Cardiology, vol. 40, no. 6, pp. 1253-1257. https://doi.org/10.1007/s00246-019-02145-9

@article{21732c2264f84120ba3fa7f6b7a5a16b,

title = "Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy",

abstract = "Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients{\textquoteright} weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18–50, mean 29.1) was present in 140 children aged 2–19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.",

keywords = "Defibrillator, Hypertrophic cardiomyopathy, Obesity, Sudden death",

author = "Seshadri Balaji and DiLorenzo, {Michael P.} and Fish, {Frank A.} and Etheridge, {Susan P.} and Aziz, {Peter F.} and Russell, {Mark W.} and Svjetlana Tisma and Andreas Pflaumer and Narayanswami Sreeram and Peter Kubus and Law, {Ian H.} and Kantoch, {Michal J.} and Kertesz, {Naomi J.} and Margaret Strieper and Erickson, {Christopher C.} and Moore, {Jeremy P.} and Nakano, {Stephanie J.} and Singh, {Harinder R.} and Philip Chang and Mitchell Cohen and Anne Fournier and Ilina, {Maria V.} and Smith, {Richard T.} and Frank Zimmerman and Michaela Horndasch and Walter Li and Anjan Batra and Leonardo Liberman and Robert Hamilton and Janson, {Christopher M.} and Shubhayan Sanatani and Ilana Zeltser and George McDaniel and Blaufox, {Andrew D.} and Garnreiter, {Jason M.} and Hannah Katcoff and Maully Shah",

note = "Funding Information: SB: Consultancy fee MyoKardia; Advisory Board, yoR labs. PK: Supported by Ministry of Health, Czech Republic; CCE: Cosultancy Fee Medtronic; JPM: Research Grants, Biotronik. All others: None. Funding Information: This study was supported by Medtronic External Research Protocol number CR-1651. Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2019",

month = aug,

day = "15",

doi = "10.1007/s00246-019-02145-9",

language = "English (US)",

volume = "40",

pages = "1253--1257",

journal = "Pediatric Cardiology",

issn = "0172-0643",

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T1 - Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy

AU - Balaji, Seshadri

AU - DiLorenzo, Michael P.

AU - Fish, Frank A.

AU - Etheridge, Susan P.

AU - Aziz, Peter F.

AU - Russell, Mark W.

AU - Tisma, Svjetlana

AU - Pflaumer, Andreas

AU - Sreeram, Narayanswami

AU - Kubus, Peter

AU - Law, Ian H.

AU - Kantoch, Michal J.

AU - Kertesz, Naomi J.

AU - Strieper, Margaret

AU - Erickson, Christopher C.

AU - Moore, Jeremy P.

AU - Nakano, Stephanie J.

AU - Singh, Harinder R.

AU - Chang, Philip

AU - Cohen, Mitchell

AU - Fournier, Anne

AU - Ilina, Maria V.

AU - Smith, Richard T.

AU - Zimmerman, Frank

AU - Horndasch, Michaela

AU - Li, Walter

AU - Batra, Anjan

AU - Liberman, Leonardo

AU - Hamilton, Robert

AU - Janson, Christopher M.

AU - Sanatani, Shubhayan

AU - Zeltser, Ilana

AU - McDaniel, George

AU - Blaufox, Andrew D.

AU - Garnreiter, Jason M.

AU - Katcoff, Hannah

AU - Shah, Maully

N1 - Funding Information: SB: Consultancy fee MyoKardia; Advisory Board, yoR labs. PK: Supported by Ministry of Health, Czech Republic; CCE: Cosultancy Fee Medtronic; JPM: Research Grants, Biotronik. All others: None. Funding Information: This study was supported by Medtronic External Research Protocol number CR-1651. Publisher Copyright: © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients’ weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18–50, mean 29.1) was present in 140 children aged 2–19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.

AB - Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients’ weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18–50, mean 29.1) was present in 140 children aged 2–19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.

KW - Defibrillator

KW - Hypertrophic cardiomyopathy

KW - Obesity

KW - Sudden death

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JO - Pediatric Cardiology

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ER -

Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy

Abstract

Keywords

ASJC Scopus subject areas

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