Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy

Seshadri Balaji, Michael P. DiLorenzo, Frank A. Fish, Susan P. Etheridge, Peter F. Aziz, Mark W. Russell, Svjetlana Tisma, Andreas Pflaumer, Narayanswami Sreeram, Peter Kubus, Ian H. Law, Michal J. Kantoch, Naomi J. Kertesz, Margaret Strieper, Christopher C. Erickson, Jeremy P. Moore, Stephanie J. Nakano, Harinder R. Singh, Philip Chang, Mitchell CohenAnne Fournier, Maria V. Ilina, Richard T. Smith, Frank Zimmerman, Michaela Horndasch, Walter Li, Anjan Batra, Leonardo Liberman, Robert Hamilton, Christopher M. Janson, Shubhayan Sanatani, Ilana Zeltser, George McDaniel, Andrew D. Blaufox, Jason M. Garnreiter, Hannah Katcoff, Maully Shah

Research output: Contribution to journalArticle

Abstract

Obesity is associated with additional left ventricular hypertrophy (LVH) in adults with hypertrophic cardiomyopathy (HCM). It is not known whether obesity can lead to further LVH in children with HCM. Echocardiographic LV dimensions were determined in 504 children with HCM. Measurements of interventricular septal thickness (IVST) and posterior wall thickness (PWT), and patients’ weight and height were recorded. Obesity was defined as a body mass index (BMI) ≥ 99th percentile for age and sex. IVST data was available for 498 and PWT data for 484 patients. Patient age ranged from 2 to 20 years (mean ± SD, 12.5 ± 3.9) and 340 (68%) were males. Overall, patient BMI ranged from 7 to 50 (22.7 ± 6.1). Obesity (BMI 18–50, mean 29.1) was present in 140 children aged 2–19.6 (11.3 ± 4.1). The overall mean IVST was 20.5 ± 9.6 mm and the overall mean PWT was 11.0 ± 8.4 mm. The mean IVST in the obese patients was 21.6 ± 10.0 mm and mean PWT was 13.3 ± 14.7 mm. The mean IVST in the non-obese patients was 20.1 ± 9.5 mm and mean PWT was 10.4 ± 4.3 mm. Obesity was not significantly associated with IVST (p = 0.12), but was associated with increased PWT (0.0011). Obesity is associated with increased PWT but not IVST in children with HCM. Whether obesity and its impact on LVH influences clinical outcomes in children with HCM needs to be studied.

Original languageEnglish (US)
Pages (from-to)1253-1257
Number of pages5
JournalPediatric Cardiology
Volume40
Issue number6
DOIs
StatePublished - Aug 15 2019

Keywords

  • Defibrillator
  • Hypertrophic cardiomyopathy
  • Obesity
  • Sudden death

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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    Balaji, S., DiLorenzo, M. P., Fish, F. A., Etheridge, S. P., Aziz, P. F., Russell, M. W., Tisma, S., Pflaumer, A., Sreeram, N., Kubus, P., Law, I. H., Kantoch, M. J., Kertesz, N. J., Strieper, M., Erickson, C. C., Moore, J. P., Nakano, S. J., Singh, H. R., Chang, P., ... Shah, M. (2019). Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy. Pediatric Cardiology, 40(6), 1253-1257. https://doi.org/10.1007/s00246-019-02145-9