Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Aliye Uc, M. Bridget Zimmerman, Michael Wilschanski, Steven L. Werlin, David Troendle, Uzma Shah, Sarah Jane Schwarzenberg, Sue Rhee, John F. Pohl, Emily R. Perito, Joseph J. Palermo, Chee Y. Ooi, Quin Liu, Tom K. Lin, Veronique D. Morinville, Brian A. McFerron, Sohail Z. Husain, Ryan Himes, Melvin B. Heyman, Tanja GonskaMatthew J. Giefer, Cheryl E. Gariepy, Steven D. Freedman, Douglas S. Fishman, Melena D. Bellin, Bradley Barth, Maisam Abu-El-Haija, Mark E. Lowe

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

Original languageEnglish (US)
Pages (from-to)967-973
Number of pages7
JournalPancreas
Volume47
Issue number8
DOIs
StatePublished - Sep 1 2018

    Fingerprint

Keywords

  • body mass index
  • children
  • pancreatitis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Uc, A., Zimmerman, M. B., Wilschanski, M., Werlin, S. L., Troendle, D., Shah, U., Schwarzenberg, S. J., Rhee, S., Pohl, J. F., Perito, E. R., Palermo, J. J., Ooi, C. Y., Liu, Q., Lin, T. K., Morinville, V. D., McFerron, B. A., Husain, S. Z., Himes, R., Heyman, M. B., ... Lowe, M. E. (2018). Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. Pancreas, 47(8), 967-973. https://doi.org/10.1097/MPA.0000000000001120