Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Aliye Uc; M. Bridget Zimmerman; Michael Wilschanski; Steven L. Werlin; David Troendle; Uzma Shah; Sarah Jane Schwarzenberg; Sue Rhee; John F. Pohl; Emily R. Perito; Joseph J. Palermo; Chee Y. Ooi; Quin Liu; Tom K. Lin; Veronique D. Morinville; Brian A. McFerron; Sohail Z. Husain; Ryan Himes; Melvin B. Heyman; Tanja Gonska; Matthew J. Giefer; Cheryl E. Gariepy; Steven D. Freedman; Douglas S. Fishman; Melena D. Bellin; Bradley Barth; Maisam Abu-El-Haija; Mark E. Lowe

doi:10.1097/MPA.0000000000001120

Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Aliye Uc, M. Bridget Zimmerman, Michael Wilschanski, Steven L. Werlin, David Troendle, Uzma Shah, Sarah Jane Schwarzenberg, Sue Rhee, John F. Pohl, Emily R. Perito, Joseph J. Palermo, Chee Y. Ooi, Quin Liu, Tom K. Lin, Veronique D. Morinville, Brian A. McFerron, Sohail Z. Husain, Ryan Himes, Melvin B. Heyman, Tanja GonskaMatthew J. Giefer, Cheryl E. Gariepy, Steven D. Freedman, Douglas S. Fishman, Melena D. Bellin, Bradley Barth, Maisam Abu-El-Haija, Mark E. Lowe

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

Original language	English (US)
Pages (from-to)	967-973
Number of pages	7
Journal	Pancreas
Volume	47
Issue number	8
DOIs	https://doi.org/10.1097/MPA.0000000000001120
State	Published - Sep 1 2018

Keywords

body mass index
children
pancreatitis

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

Access to Document

10.1097/MPA.0000000000001120

Cite this

Uc, A., Zimmerman, M. B., Wilschanski, M., Werlin, S. L., Troendle, D., Shah, U., Schwarzenberg, S. J., Rhee, S., Pohl, J. F., Perito, E. R., Palermo, J. J., Ooi, C. Y., Liu, Q., Lin, T. K., Morinville, V. D., McFerron, B. A., Husain, S. Z., Himes, R., Heyman, M. B., ... Lowe, M. E. (2018). Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. Pancreas, 47(8), 967-973. https://doi.org/10.1097/MPA.0000000000001120

Uc, A, Zimmerman, MB, Wilschanski, M, Werlin, SL, Troendle, D, Shah, U, Schwarzenberg, SJ, Rhee, S, Pohl, JF, Perito, ER, Palermo, JJ, Ooi, CY, Liu, Q, Lin, TK, Morinville, VD, McFerron, BA, Husain, SZ, Himes, R, Heyman, MB, Gonska, T, Giefer, MJ, Gariepy, CE, Freedman, SD, Fishman, DS, Bellin, MD, Barth, B, Abu-El-Haija, M & Lowe, ME 2018, 'Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis', Pancreas, vol. 47, no. 8, pp. 967-973. https://doi.org/10.1097/MPA.0000000000001120

@article{8ffe30dd45f14970890b6a8609df328b,

title = "Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis",

abstract = "Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.",

keywords = "body mass index, children, pancreatitis",

author = "Aliye Uc and Zimmerman, {M. Bridget} and Michael Wilschanski and Werlin, {Steven L.} and David Troendle and Uzma Shah and Schwarzenberg, {Sarah Jane} and Sue Rhee and Pohl, {John F.} and Perito, {Emily R.} and Palermo, {Joseph J.} and Ooi, {Chee Y.} and Quin Liu and Lin, {Tom K.} and Morinville, {Veronique D.} and McFerron, {Brian A.} and Husain, {Sohail Z.} and Ryan Himes and Heyman, {Melvin B.} and Tanja Gonska and Giefer, {Matthew J.} and Gariepy, {Cheryl E.} and Freedman, {Steven D.} and Fishman, {Douglas S.} and Bellin, {Melena D.} and Bradley Barth and Maisam Abu-El-Haija and Lowe, {Mark E.}",

note = "Funding Information: A.U. is supported by the National Institutes of Health grants (R21 DK096327, U01 DK108334, R01 DK097820); INSPPIRE registry was developed by CTSA (2UL1 TR000442) and REDCap. Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",

year = "2018",

month = sep,

day = "1",

doi = "10.1097/MPA.0000000000001120",

language = "English (US)",

volume = "47",

pages = "967--973",

journal = "Pancreas",

issn = "0885-3177",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

TY - JOUR

T1 - Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

AU - Uc, Aliye

AU - Zimmerman, M. Bridget

AU - Wilschanski, Michael

AU - Werlin, Steven L.

AU - Troendle, David

AU - Shah, Uzma

AU - Schwarzenberg, Sarah Jane

AU - Rhee, Sue

AU - Pohl, John F.

AU - Perito, Emily R.

AU - Palermo, Joseph J.

AU - Ooi, Chee Y.

AU - Liu, Quin

AU - Lin, Tom K.

AU - Morinville, Veronique D.

AU - McFerron, Brian A.

AU - Husain, Sohail Z.

AU - Himes, Ryan

AU - Heyman, Melvin B.

AU - Gonska, Tanja

AU - Giefer, Matthew J.

AU - Gariepy, Cheryl E.

AU - Freedman, Steven D.

AU - Fishman, Douglas S.

AU - Bellin, Melena D.

AU - Barth, Bradley

AU - Abu-El-Haija, Maisam

AU - Lowe, Mark E.

N1 - Funding Information: A.U. is supported by the National Institutes of Health grants (R21 DK096327, U01 DK108334, R01 DK097820); INSPPIRE registry was developed by CTSA (2UL1 TR000442) and REDCap. Publisher Copyright: © Wolters Kluwer Health, Inc. All rights reserved.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

AB - Objective The aim of this study was to assess the impact of obesity on pediatric acute recurrent pancreatitis or chronic pancreatitis (CP). Methods We determined body mass index (BMI) status at enrollment in INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) cohort using CDC criteria for pediatric-specific BMI percentiles. We used the Cochran-Armitage test to assess trends and the Jonckheere-Terpstra test to determine associations. Results Of 446 subjects (acute recurrent pancreatitis, n = 241; CP, n = 205), 22 were underweight, 258 normal weight, 75 overweight, and 91 were obese. The BMI groups were similar in sex, race, and age at presentation. Hypertriglyceridemia was more common in overweight or obese. Obese children were less likely to have CP and more likely to have acute inflammation on imaging. Compared with children with normal weight, obese or overweight children were older at first acute pancreatitis episode and diagnosed with CP at an older age. Obese or overweight children were less likely to undergo medical or endoscopic treatment, develop exocrine pancreatic insufficiency, and require total pancreatectomy with islet autotransplantation. Diabetes was similar among all groups. Conclusions Obesity or overweight seems to delay the initial acute pancreatitis episode and diagnosis of CP compared with normal weight or underweight. The impact of obesity on pediatric CP progression and severity deserves further study.

KW - body mass index

KW - children

KW - pancreatitis

UR - http://www.scopus.com/inward/record.url?scp=85051951074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051951074&partnerID=8YFLogxK

U2 - 10.1097/MPA.0000000000001120

DO - 10.1097/MPA.0000000000001120

M3 - Article

C2 - 30059474

AN - SCOPUS:85051951074

SN - 0885-3177

VL - 47

SP - 967

EP - 973

JO - Pancreas

JF - Pancreas

IS - 8

ER -

Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this