Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy

M. Rieken, L. A. Kluth, E. Xylinas, C. Seitz, H. Fajkovic, P. I. Karakiewicz, Yair Lotan, A. Briganti, W. Loidl, T. Faison, J. J. Crivelli, D. S. Scherr, A. Bachmann, A. K. Tewari, A. Kautzky-Willer, K. Pummer, S. F. Shariat

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background:The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.Methods: We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni-and multivariable cox regression models addressed the association of statin use with BCR.Results:Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values ≤0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82%±1 for patients without statin use and 84±1% for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76-1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features.Conclusions:In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalProstate Cancer and Prostatic Diseases
Volume16
Issue number4
DOIs
StatePublished - Dec 2013

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Prostatectomy
Recurrence
Prostatic Neoplasms
Proportional Hazards Models
Confidence Intervals
Survival

Keywords

  • Biochemical recurrence
  • Radical prostatectomy
  • Statins

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

Rieken, M., Kluth, L. A., Xylinas, E., Seitz, C., Fajkovic, H., Karakiewicz, P. I., ... Shariat, S. F. (2013). Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy. Prostate Cancer and Prostatic Diseases, 16(4), 367-371. https://doi.org/10.1038/pcan.2013.31

Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy. / Rieken, M.; Kluth, L. A.; Xylinas, E.; Seitz, C.; Fajkovic, H.; Karakiewicz, P. I.; Lotan, Yair; Briganti, A.; Loidl, W.; Faison, T.; Crivelli, J. J.; Scherr, D. S.; Bachmann, A.; Tewari, A. K.; Kautzky-Willer, A.; Pummer, K.; Shariat, S. F.

In: Prostate Cancer and Prostatic Diseases, Vol. 16, No. 4, 12.2013, p. 367-371.

Research output: Contribution to journalArticle

Rieken, M, Kluth, LA, Xylinas, E, Seitz, C, Fajkovic, H, Karakiewicz, PI, Lotan, Y, Briganti, A, Loidl, W, Faison, T, Crivelli, JJ, Scherr, DS, Bachmann, A, Tewari, AK, Kautzky-Willer, A, Pummer, K & Shariat, SF 2013, 'Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy', Prostate Cancer and Prostatic Diseases, vol. 16, no. 4, pp. 367-371. https://doi.org/10.1038/pcan.2013.31
Rieken, M. ; Kluth, L. A. ; Xylinas, E. ; Seitz, C. ; Fajkovic, H. ; Karakiewicz, P. I. ; Lotan, Yair ; Briganti, A. ; Loidl, W. ; Faison, T. ; Crivelli, J. J. ; Scherr, D. S. ; Bachmann, A. ; Tewari, A. K. ; Kautzky-Willer, A. ; Pummer, K. ; Shariat, S. F. / Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy. In: Prostate Cancer and Prostatic Diseases. 2013 ; Vol. 16, No. 4. pp. 367-371.
@article{93e17da10c004c92b5573e57d3f35252,
title = "Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy",
abstract = "Background:The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.Methods: We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni-and multivariable cox regression models addressed the association of statin use with BCR.Results:Overall, 2275 (33.3{\%}) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values ≤0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4{\%}) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82{\%}±1 for patients without statin use and 84±1{\%} for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95{\%} confidence interval: 0.76-1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features.Conclusions:In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.",
keywords = "Biochemical recurrence, Radical prostatectomy, Statins",
author = "M. Rieken and Kluth, {L. A.} and E. Xylinas and C. Seitz and H. Fajkovic and Karakiewicz, {P. I.} and Yair Lotan and A. Briganti and W. Loidl and T. Faison and Crivelli, {J. J.} and Scherr, {D. S.} and A. Bachmann and Tewari, {A. K.} and A. Kautzky-Willer and K. Pummer and Shariat, {S. F.}",
year = "2013",
month = "12",
doi = "10.1038/pcan.2013.31",
language = "English (US)",
volume = "16",
pages = "367--371",
journal = "Prostate Cancer and Prostatic Diseases",
issn = "1365-7852",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy

AU - Rieken, M.

AU - Kluth, L. A.

AU - Xylinas, E.

AU - Seitz, C.

AU - Fajkovic, H.

AU - Karakiewicz, P. I.

AU - Lotan, Yair

AU - Briganti, A.

AU - Loidl, W.

AU - Faison, T.

AU - Crivelli, J. J.

AU - Scherr, D. S.

AU - Bachmann, A.

AU - Tewari, A. K.

AU - Kautzky-Willer, A.

AU - Pummer, K.

AU - Shariat, S. F.

PY - 2013/12

Y1 - 2013/12

N2 - Background:The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.Methods: We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni-and multivariable cox regression models addressed the association of statin use with BCR.Results:Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values ≤0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82%±1 for patients without statin use and 84±1% for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76-1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features.Conclusions:In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.

AB - Background:The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.Methods: We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni-and multivariable cox regression models addressed the association of statin use with BCR.Results:Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values ≤0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82%±1 for patients without statin use and 84±1% for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76-1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features.Conclusions:In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.

KW - Biochemical recurrence

KW - Radical prostatectomy

KW - Statins

UR - http://www.scopus.com/inward/record.url?scp=84887613699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887613699&partnerID=8YFLogxK

U2 - 10.1038/pcan.2013.31

DO - 10.1038/pcan.2013.31

M3 - Article

C2 - 23999669

AN - SCOPUS:84887613699

VL - 16

SP - 367

EP - 371

JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

SN - 1365-7852

IS - 4

ER -