Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy

M. Rieken, L. A. Kluth, E. Xylinas, C. Seitz, H. Fajkovic, P. I. Karakiewicz, Yair Lotan, A. Briganti, W. Loidl, T. Faison, J. J. Crivelli, D. S. Scherr, A. Bachmann, A. K. Tewari, A. Kautzky-Willer, K. Pummer, S. F. Shariat

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background:The impact of statin use on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) remains controversial.Methods: We retrospectively evaluated 6842 patients who underwent RP for clinically localized prostate cancer (PC) between 2000 and 2011. Uni-and multivariable cox regression models addressed the association of statin use with BCR.Results:Overall, 2275 (33.3%) patients used statins. Statin users were older and had a higher rate of positive surgical margins than patients not using statins (P-values ≤0.05). Within a median follow-up of 25 months (interquartile range: 8-42 months), 778 (11.4%) patients experienced BCR. Actuarial estimate 5-years BCR-free survival was 82%±1 for patients without statin use and 84±1% for patients using statins (P=0.05); statin use was not associated with BCR (hazard ratio: 0.88, 95% confidence interval: 0.76-1.03, P=0.10) after adjusting for the effects of standard clinicopathologic features.Conclusions:In PC patients undergoing RP, statin use was not independently associated with lower risk of BCR.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalProstate Cancer and Prostatic Diseases
Volume16
Issue number4
DOIs
StatePublished - Dec 1 2013

Keywords

  • Biochemical recurrence
  • Radical prostatectomy
  • Statins

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

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    Rieken, M., Kluth, L. A., Xylinas, E., Seitz, C., Fajkovic, H., Karakiewicz, P. I., Lotan, Y., Briganti, A., Loidl, W., Faison, T., Crivelli, J. J., Scherr, D. S., Bachmann, A., Tewari, A. K., Kautzky-Willer, A., Pummer, K., & Shariat, S. F. (2013). Impact of statin use on biochemical recurrence in patients treated with radical prostatectomy. Prostate Cancer and Prostatic Diseases, 16(4), 367-371. https://doi.org/10.1038/pcan.2013.31