TY - JOUR
T1 - Impact of tissue volume and purification on clinical autologous islet transplantation for the treatment of chronic pancreatitis
AU - Matsumoto, Shinichi
AU - Takita, Morihito
AU - Shimoda, Masayuki
AU - Sugimoto, Koji
AU - Itoh, Takeshi
AU - Chujo, Daisuke
AU - SoRelle, Jeffery A.
AU - Tamura, Yoshiko
AU - Rahman, Ana M.
AU - Onaca, Nicholas
AU - Naziruddin, Bashoo
AU - Levy, Marlon F.
N1 - Funding Information:
The present research was carried out according to the State assignment BINM SB RAS (project no.0339-2016-0007). Supported in part by the Russian Foundation of Basic Research (project no. 18-03-00557, 18-08-00779).
PY - 2012
Y1 - 2012
N2 - Autologous islet transplantation after total pancreatectomy is an excellent treatment for painful chronic pancreatitis. Traditionally, islets have been isolated without purification; however, purification is applied when the tissue volume is large. Nevertheless, the impact of tissue volume and islet purification on clinical outcomes of autologous islet transplantation has not been well examined. We analyzed 27 cases of autologous islet transplantation performed from October 2006 to January 2011. After examining the relationship between tissue volume and portal pressure at various time points, we compared islet characteristics and clinical outcomes between cases with complications (complication group) and without (noncomplication group), as well as cases with purification (purification group) and without (nonpurification group). Tissue volume significantly correlated with maximum (R = 0.61), final (R = 0.53), and delta (i.e., difference between base and maximum; R = 0.71) portal pressure. The complication group had a significantly higher body mass index, tissue volume, islet yield, and portal pressure (maximum, final, delta), suggesting that complications were associated with high tissue volume and high portal pressure. Only one of four patients (25%) in the complication group became insulin free, whereas 11 of 23 patients (49%) in the noncomplication group became insulin free with smaller islet yields. The purification group had a higher islet yield and insulin independence rate but had similar final tissue volume, portal pressure, and complication rates compared with the nonpurification group. In conclusion, high tissue volume was associated with high portal pressure and complications in autologous islet transplantation. Islet purification effectively reduced tissue volume and had no negative impact on islet characteristics. Therefore, islet purification can reduce the risk of complications and may improve clinical outcome for autologous islet transplantation when tissue volume is large.
AB - Autologous islet transplantation after total pancreatectomy is an excellent treatment for painful chronic pancreatitis. Traditionally, islets have been isolated without purification; however, purification is applied when the tissue volume is large. Nevertheless, the impact of tissue volume and islet purification on clinical outcomes of autologous islet transplantation has not been well examined. We analyzed 27 cases of autologous islet transplantation performed from October 2006 to January 2011. After examining the relationship between tissue volume and portal pressure at various time points, we compared islet characteristics and clinical outcomes between cases with complications (complication group) and without (noncomplication group), as well as cases with purification (purification group) and without (nonpurification group). Tissue volume significantly correlated with maximum (R = 0.61), final (R = 0.53), and delta (i.e., difference between base and maximum; R = 0.71) portal pressure. The complication group had a significantly higher body mass index, tissue volume, islet yield, and portal pressure (maximum, final, delta), suggesting that complications were associated with high tissue volume and high portal pressure. Only one of four patients (25%) in the complication group became insulin free, whereas 11 of 23 patients (49%) in the noncomplication group became insulin free with smaller islet yields. The purification group had a higher islet yield and insulin independence rate but had similar final tissue volume, portal pressure, and complication rates compared with the nonpurification group. In conclusion, high tissue volume was associated with high portal pressure and complications in autologous islet transplantation. Islet purification effectively reduced tissue volume and had no negative impact on islet characteristics. Therefore, islet purification can reduce the risk of complications and may improve clinical outcome for autologous islet transplantation when tissue volume is large.
KW - Autologous islet transplantation
KW - Portal pressure
KW - Portal thrombosis
KW - Purification
KW - Tissue volume
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U2 - 10.3727/096368911X623899
DO - 10.3727/096368911X623899
M3 - Article
C2 - 22305295
AN - SCOPUS:84930475218
SN - 0963-6897
VL - 21
SP - 625
EP - 632
JO - Cell Transplantation
JF - Cell Transplantation
IS - 4
ER -