Impact of total body weight on 30-day mortality in patients with gram-negative bacteremia

Ronald G. Hall, Eunice D. Yoo, Andrew C. Faust, Terri Smith, Edward L. Goodman, Eric M. Mortensen, Steven Richardson, Carlos A. Alvarez

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: The impact of total body weight (TBW) on 30-day mortality associated with gram-negative bacteremia has not been previously evaluated. Methods: The cohort included 323 patients >/ = 18 years old with gram-negative bacteremia (1/1/2008–8/31/2011) who received >/ = 48 hours of antibiotics. We compared 30-day mortality of TBW <70 kg vs. >/ = 70 kg with a multivariable stepwise logistic regression adjusting for age >/ = 70 years, cancer diagnosis, and Pitt bacteremia score of >/ = 4. Results: The cohort was 57% TBW >/ = 70 kg and 43% TBW <70 kg. TBW >/ = 70 kg patients had lower 30-day mortality (11.0% vs. 16.3%), which was significant in the multivariable analysis (OR 0.45, 95% CI 0.21–0.97). Cancer and Pitt bacteremia score >/ = 4 were also independently associated with 30-day mortality. TBW was no longer significant when TBW <50 kg patients were excluded. Conclusion: TBW >/ = 70 kg was associated with an improved 30-day mortality; however, the high mortality rates for patients with a TBW < 50 kg is responsible for this association.

Original languageEnglish (US)
Pages (from-to)797-803
Number of pages7
JournalExpert Review of Anti-Infective Therapy
Volume15
Issue number8
DOIs
StatePublished - Aug 3 2017

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Keywords

  • Escherichia coli
  • Gram-negative
  • Klebsiella sp
  • bacteremia
  • total body weight

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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