Impact of total body weight on 30-day mortality in patients with gram-negative bacteremia

Ronald G. Hall, Eunice D. Yoo, Andrew C. Faust, Terri Smith, Edward L. Goodman, Eric M. Mortensen, Steven Richardson, Carlos A. Alvarez

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The impact of total body weight (TBW) on 30-day mortality associated with gram-negative bacteremia has not been previously evaluated. Methods: The cohort included 323 patients >/ = 18 years old with gram-negative bacteremia (1/1/2008–8/31/2011) who received >/ = 48 hours of antibiotics. We compared 30-day mortality of TBW <70 kg vs. >/ = 70 kg with a multivariable stepwise logistic regression adjusting for age >/ = 70 years, cancer diagnosis, and Pitt bacteremia score of >/ = 4. Results: The cohort was 57% TBW >/ = 70 kg and 43% TBW <70 kg. TBW >/ = 70 kg patients had lower 30-day mortality (11.0% vs. 16.3%), which was significant in the multivariable analysis (OR 0.45, 95% CI 0.21–0.97). Cancer and Pitt bacteremia score >/ = 4 were also independently associated with 30-day mortality. TBW was no longer significant when TBW <50 kg patients were excluded. Conclusion: TBW >/ = 70 kg was associated with an improved 30-day mortality; however, the high mortality rates for patients with a TBW < 50 kg is responsible for this association.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalExpert Review of Anti-Infective Therapy
DOIs
StateAccepted/In press - May 18 2017

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Bacteremia
Body Weight
Mortality
Neoplasms
Logistic Models
Anti-Bacterial Agents

Keywords

  • bacteremia
  • Escherichia coli
  • Gram-negative
  • Klebsiella sp
  • total body weight

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

Impact of total body weight on 30-day mortality in patients with gram-negative bacteremia. / Hall, Ronald G.; Yoo, Eunice D.; Faust, Andrew C.; Smith, Terri; Goodman, Edward L.; Mortensen, Eric M.; Richardson, Steven; Alvarez, Carlos A.

In: Expert Review of Anti-Infective Therapy, 18.05.2017, p. 1-7.

Research output: Contribution to journalArticle

Hall, Ronald G. ; Yoo, Eunice D. ; Faust, Andrew C. ; Smith, Terri ; Goodman, Edward L. ; Mortensen, Eric M. ; Richardson, Steven ; Alvarez, Carlos A. / Impact of total body weight on 30-day mortality in patients with gram-negative bacteremia. In: Expert Review of Anti-Infective Therapy. 2017 ; pp. 1-7.
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abstract = "Background: The impact of total body weight (TBW) on 30-day mortality associated with gram-negative bacteremia has not been previously evaluated. Methods: The cohort included 323 patients >/ = 18 years old with gram-negative bacteremia (1/1/2008–8/31/2011) who received >/ = 48 hours of antibiotics. We compared 30-day mortality of TBW <70 kg vs. >/ = 70 kg with a multivariable stepwise logistic regression adjusting for age >/ = 70 years, cancer diagnosis, and Pitt bacteremia score of >/ = 4. Results: The cohort was 57{\%} TBW >/ = 70 kg and 43{\%} TBW <70 kg. TBW >/ = 70 kg patients had lower 30-day mortality (11.0{\%} vs. 16.3{\%}), which was significant in the multivariable analysis (OR 0.45, 95{\%} CI 0.21–0.97). Cancer and Pitt bacteremia score >/ = 4 were also independently associated with 30-day mortality. TBW was no longer significant when TBW <50 kg patients were excluded. Conclusion: TBW >/ = 70 kg was associated with an improved 30-day mortality; however, the high mortality rates for patients with a TBW < 50 kg is responsible for this association.",
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AU - Richardson, Steven

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N2 - Background: The impact of total body weight (TBW) on 30-day mortality associated with gram-negative bacteremia has not been previously evaluated. Methods: The cohort included 323 patients >/ = 18 years old with gram-negative bacteremia (1/1/2008–8/31/2011) who received >/ = 48 hours of antibiotics. We compared 30-day mortality of TBW <70 kg vs. >/ = 70 kg with a multivariable stepwise logistic regression adjusting for age >/ = 70 years, cancer diagnosis, and Pitt bacteremia score of >/ = 4. Results: The cohort was 57% TBW >/ = 70 kg and 43% TBW <70 kg. TBW >/ = 70 kg patients had lower 30-day mortality (11.0% vs. 16.3%), which was significant in the multivariable analysis (OR 0.45, 95% CI 0.21–0.97). Cancer and Pitt bacteremia score >/ = 4 were also independently associated with 30-day mortality. TBW was no longer significant when TBW <50 kg patients were excluded. Conclusion: TBW >/ = 70 kg was associated with an improved 30-day mortality; however, the high mortality rates for patients with a TBW < 50 kg is responsible for this association.

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