Impact of toxigenic clostridium difficile colonization on the risk of subsequent C. Difficile infection in intensive care unit patients

Sarah Tschudin-Sutter, Karen C. Carroll, Pranita D. Tamma, Madeleine L. Sudekum, Reno Frei, Andreas F. Widmer, Brandon C. Ellis, John Bartlett, Trish M. Perl

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

background. Clostridium difficile infection (CDI) in hospitalized patients is generally attributed to the current stay, but recent studies reveal high C. difficile colonization rates on admission. objective. To determine the rate of colonization with toxigenic C. difficile among intensive care unit patients upon admission as well as acquired during hospitalization, and the risk of subsequent CDI. methods. Prospective cohort study from April 15 through July 8, 2013. Adults admitted to an intensive care unit within 48 hours of admission to the Johns Hopkins Hospital, Baltimore, Maryland, were screened for colonization with toxigenic C. difficile. The primary outcome was risk of developing CDI. results. Among 542 patients, 17 (3.1%) were colonized with toxigenic C. difficile on admission and an additional 3 patients were found to be colonized during hospitalization. Both colonization with toxigenic C. difficile on admission and colonization during hospitalization were associated with an increased risk for development of CDI (relative risk, 10.29 [95% CI, 2.24–47.40], P=.003; and 15.66 [4.01–61.08], P<.001, respectively). Using multivariable analysis, colonization on admission and colonization during hospitalization were independent predictors of CDI (relative risk, 8.62 [95% CI, 1.48–50.25], P=.017; and 10.93 [1.49–80.20], P=.019, respectively), while adjusting for potential confounders. conclusions. In intensive care unit patients, colonization with toxigenic C. difficile is an independent risk factor for development of subsequent CDI. Further studies are needed to identify populations with higher toxigenic C. difficile colonization rates possibly benefiting from screening or avoidance of agents known to promote CDI.

Original languageEnglish (US)
Pages (from-to)1324-1329
Number of pages6
JournalInfection Control and Hospital Epidemiology
Volume36
Issue number11
DOIs
StatePublished - Jan 1 2015

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Clostridium difficile
Intensive Care Units
Clostridium Infections
Infection
Hospitalization
Baltimore
Patient Admission

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Impact of toxigenic clostridium difficile colonization on the risk of subsequent C. Difficile infection in intensive care unit patients. / Tschudin-Sutter, Sarah; Carroll, Karen C.; Tamma, Pranita D.; Sudekum, Madeleine L.; Frei, Reno; Widmer, Andreas F.; Ellis, Brandon C.; Bartlett, John; Perl, Trish M.

In: Infection Control and Hospital Epidemiology, Vol. 36, No. 11, 01.01.2015, p. 1324-1329.

Research output: Contribution to journalArticle

Tschudin-Sutter, Sarah ; Carroll, Karen C. ; Tamma, Pranita D. ; Sudekum, Madeleine L. ; Frei, Reno ; Widmer, Andreas F. ; Ellis, Brandon C. ; Bartlett, John ; Perl, Trish M. / Impact of toxigenic clostridium difficile colonization on the risk of subsequent C. Difficile infection in intensive care unit patients. In: Infection Control and Hospital Epidemiology. 2015 ; Vol. 36, No. 11. pp. 1324-1329.
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abstract = "background. Clostridium difficile infection (CDI) in hospitalized patients is generally attributed to the current stay, but recent studies reveal high C. difficile colonization rates on admission. objective. To determine the rate of colonization with toxigenic C. difficile among intensive care unit patients upon admission as well as acquired during hospitalization, and the risk of subsequent CDI. methods. Prospective cohort study from April 15 through July 8, 2013. Adults admitted to an intensive care unit within 48 hours of admission to the Johns Hopkins Hospital, Baltimore, Maryland, were screened for colonization with toxigenic C. difficile. The primary outcome was risk of developing CDI. results. Among 542 patients, 17 (3.1{\%}) were colonized with toxigenic C. difficile on admission and an additional 3 patients were found to be colonized during hospitalization. Both colonization with toxigenic C. difficile on admission and colonization during hospitalization were associated with an increased risk for development of CDI (relative risk, 10.29 [95{\%} CI, 2.24–47.40], P=.003; and 15.66 [4.01–61.08], P<.001, respectively). Using multivariable analysis, colonization on admission and colonization during hospitalization were independent predictors of CDI (relative risk, 8.62 [95{\%} CI, 1.48–50.25], P=.017; and 10.93 [1.49–80.20], P=.019, respectively), while adjusting for potential confounders. conclusions. In intensive care unit patients, colonization with toxigenic C. difficile is an independent risk factor for development of subsequent CDI. Further studies are needed to identify populations with higher toxigenic C. difficile colonization rates possibly benefiting from screening or avoidance of agents known to promote CDI.",
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T1 - Impact of toxigenic clostridium difficile colonization on the risk of subsequent C. Difficile infection in intensive care unit patients

AU - Tschudin-Sutter, Sarah

AU - Carroll, Karen C.

AU - Tamma, Pranita D.

AU - Sudekum, Madeleine L.

AU - Frei, Reno

AU - Widmer, Andreas F.

AU - Ellis, Brandon C.

AU - Bartlett, John

AU - Perl, Trish M.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - background. Clostridium difficile infection (CDI) in hospitalized patients is generally attributed to the current stay, but recent studies reveal high C. difficile colonization rates on admission. objective. To determine the rate of colonization with toxigenic C. difficile among intensive care unit patients upon admission as well as acquired during hospitalization, and the risk of subsequent CDI. methods. Prospective cohort study from April 15 through July 8, 2013. Adults admitted to an intensive care unit within 48 hours of admission to the Johns Hopkins Hospital, Baltimore, Maryland, were screened for colonization with toxigenic C. difficile. The primary outcome was risk of developing CDI. results. Among 542 patients, 17 (3.1%) were colonized with toxigenic C. difficile on admission and an additional 3 patients were found to be colonized during hospitalization. Both colonization with toxigenic C. difficile on admission and colonization during hospitalization were associated with an increased risk for development of CDI (relative risk, 10.29 [95% CI, 2.24–47.40], P=.003; and 15.66 [4.01–61.08], P<.001, respectively). Using multivariable analysis, colonization on admission and colonization during hospitalization were independent predictors of CDI (relative risk, 8.62 [95% CI, 1.48–50.25], P=.017; and 10.93 [1.49–80.20], P=.019, respectively), while adjusting for potential confounders. conclusions. In intensive care unit patients, colonization with toxigenic C. difficile is an independent risk factor for development of subsequent CDI. Further studies are needed to identify populations with higher toxigenic C. difficile colonization rates possibly benefiting from screening or avoidance of agents known to promote CDI.

AB - background. Clostridium difficile infection (CDI) in hospitalized patients is generally attributed to the current stay, but recent studies reveal high C. difficile colonization rates on admission. objective. To determine the rate of colonization with toxigenic C. difficile among intensive care unit patients upon admission as well as acquired during hospitalization, and the risk of subsequent CDI. methods. Prospective cohort study from April 15 through July 8, 2013. Adults admitted to an intensive care unit within 48 hours of admission to the Johns Hopkins Hospital, Baltimore, Maryland, were screened for colonization with toxigenic C. difficile. The primary outcome was risk of developing CDI. results. Among 542 patients, 17 (3.1%) were colonized with toxigenic C. difficile on admission and an additional 3 patients were found to be colonized during hospitalization. Both colonization with toxigenic C. difficile on admission and colonization during hospitalization were associated with an increased risk for development of CDI (relative risk, 10.29 [95% CI, 2.24–47.40], P=.003; and 15.66 [4.01–61.08], P<.001, respectively). Using multivariable analysis, colonization on admission and colonization during hospitalization were independent predictors of CDI (relative risk, 8.62 [95% CI, 1.48–50.25], P=.017; and 10.93 [1.49–80.20], P=.019, respectively), while adjusting for potential confounders. conclusions. In intensive care unit patients, colonization with toxigenic C. difficile is an independent risk factor for development of subsequent CDI. Further studies are needed to identify populations with higher toxigenic C. difficile colonization rates possibly benefiting from screening or avoidance of agents known to promote CDI.

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