Impaired cutaneous vasodilation and sweating in grafted skin during whole-body heating

Scott L. Davis, Manabu Shibasaki, David A. Low, Jian Cui, David M. Keller, Gary F. Purdue, John L. Hunt, Brett D. Arnoldo, Karen J. Kowalske, Craig G. Crandall

Research output: Contribution to journalArticle

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Abstract

The aim of this investigation was to identify the consequences of skin grafting on cutaneous vasodilation and sweating in split-thickness grafted skin during indirect whole-body heating 5 to 9 months after surgery. In addition, thermoregulatory function was examined at donor skin sites on a separate day. Skin blood flow and sweat rate (SR) were assessed from both grafted (n = 14) or donor skin (n = 11) and compared with the respective adjacent control skin during indirect whole-body heating. Cutaneous vascular conductance (CVC) was calculated from the ratio of skin blood flow (arbitrary units; au) to mean arterial pressure. Whole-body heating significantly increased internal temperature (37.0 ± 0.1°C to 37.8 ± 0.1°C; P < .05). Cutaneous vasodilation (ie, the increase in CVC from baseline, ΔCVC) during whole-body heating was significantly attenuated in grafted skin (ΔCVC = 0.14 ± 0.15 au/mm Hg) compared with adjacent control skin (ΔCVC = 0.84 ± 0.11 au/mm Hg; P < .05). Increases in sweat rate (ΔSR) were also significantly lower in grafted skin (ΔSR = 0.08 ± 0.08 mg/cm/min) compared with adjacent control skin (ΔSR = 1.16 ± 0.20 mg/cm/min; P < .05). Cutaneous vasodilation and sweating during heating were not significantly different between donor sites (ΔCVC = 0.71 ± 0.19 au/mm Hg; ΔSR = 1.04 ± 0.15 mg/cm/min) and adjacent control skin (ΔCVC = 0.50 ± 0.10 au/mm Hg; ΔSR = 0.83 ± 0.17 mg/cm/min). Greatly attenuated or absence of cutaneous vasodilation and sweating suggests impairment of thermoregulatory function in grafted skin, thereby, diminishing the contribution of this skin to overall temperature control during a heat stress.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalJournal of Burn Care and Research
Volume28
Issue number3
DOIs
StatePublished - May 2007

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Sweating
Vasodilation
Heating
Skin
Sweat
Blood Vessels

ASJC Scopus subject areas

  • Emergency Medicine
  • Rehabilitation
  • Surgery

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Impaired cutaneous vasodilation and sweating in grafted skin during whole-body heating. / Davis, Scott L.; Shibasaki, Manabu; Low, David A.; Cui, Jian; Keller, David M.; Purdue, Gary F.; Hunt, John L.; Arnoldo, Brett D.; Kowalske, Karen J.; Crandall, Craig G.

In: Journal of Burn Care and Research, Vol. 28, No. 3, 05.2007, p. 427-434.

Research output: Contribution to journalArticle

Davis, Scott L. ; Shibasaki, Manabu ; Low, David A. ; Cui, Jian ; Keller, David M. ; Purdue, Gary F. ; Hunt, John L. ; Arnoldo, Brett D. ; Kowalske, Karen J. ; Crandall, Craig G. / Impaired cutaneous vasodilation and sweating in grafted skin during whole-body heating. In: Journal of Burn Care and Research. 2007 ; Vol. 28, No. 3. pp. 427-434.
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abstract = "The aim of this investigation was to identify the consequences of skin grafting on cutaneous vasodilation and sweating in split-thickness grafted skin during indirect whole-body heating 5 to 9 months after surgery. In addition, thermoregulatory function was examined at donor skin sites on a separate day. Skin blood flow and sweat rate (SR) were assessed from both grafted (n = 14) or donor skin (n = 11) and compared with the respective adjacent control skin during indirect whole-body heating. Cutaneous vascular conductance (CVC) was calculated from the ratio of skin blood flow (arbitrary units; au) to mean arterial pressure. Whole-body heating significantly increased internal temperature (37.0 ± 0.1°C to 37.8 ± 0.1°C; P < .05). Cutaneous vasodilation (ie, the increase in CVC from baseline, ΔCVC) during whole-body heating was significantly attenuated in grafted skin (ΔCVC = 0.14 ± 0.15 au/mm Hg) compared with adjacent control skin (ΔCVC = 0.84 ± 0.11 au/mm Hg; P < .05). Increases in sweat rate (ΔSR) were also significantly lower in grafted skin (ΔSR = 0.08 ± 0.08 mg/cm/min) compared with adjacent control skin (ΔSR = 1.16 ± 0.20 mg/cm/min; P < .05). Cutaneous vasodilation and sweating during heating were not significantly different between donor sites (ΔCVC = 0.71 ± 0.19 au/mm Hg; ΔSR = 1.04 ± 0.15 mg/cm/min) and adjacent control skin (ΔCVC = 0.50 ± 0.10 au/mm Hg; ΔSR = 0.83 ± 0.17 mg/cm/min). Greatly attenuated or absence of cutaneous vasodilation and sweating suggests impairment of thermoregulatory function in grafted skin, thereby, diminishing the contribution of this skin to overall temperature control during a heat stress.",
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AU - Purdue, Gary F.

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