Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor

Hiroshi Mashimo, Deng Chyang Wu, Daniel K. Podolsky, Mark C. Fishman

Research output: Contribution to journalArticle

566 Scopus citations

Abstract

The mechanisms that maintain the epithelial integrity of the gastrointestinal tract remain largely undefined. The gene encoding intestinal trefoil factor (ITF), a protein secreted throughout the small intestine and colon, was rendered nonfunctional in mice by targeted disruption. Mice lacking ITF had impaired mucosal healing and died from extensive colitis after oral administration of dextran sulfate sodium, an agent that causes mild epithelial injury in wild-type mice. ITF-deficient mice manifested poor epithelial regeneration after injury. These findings reveal a central role for ITF in the maintenance and repair of the intestinal mucosa.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalScience
Volume274
Issue number5285
DOIs
StatePublished - Oct 11 1996

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