Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders

M. W. Mosconi, M. Kay, A. M. D'Cruz, A. Seidenfeld, S. Guter, L. D. Stanford, J. A. Sweeney

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Abstract

Background. Impairments in executive cognitive control, including a reduced ability to inhibit prepotent responses, have been reported in autism spectrum disorders (ASD). These deficits may underlie patterns of repetitive behaviors associated with the disorder. Method. Eighteen individuals with ASD and 15 age- and IQ-matched healthy individuals performed an antisaccade task and a visually guided saccade control task, each with gap and overlap conditions. Measures of repetitive behaviors were obtained using the Autism Diagnostic Inventory - Revised (ADI-R) and examined in relation to neurocognitive task performance. Results. Individuals with an ASD showed increased rates of prosaccade errors (failures to inhibit prepotent responses) on the antisaccade task regardless of task condition (gap/overlap). Prosaccade error rates were associated with the level of higher-order (e.g. compulsions, preoccupations) but not sensorimotor repetitive behaviors in ASD. Conclusions. Neurocognitive disturbances in voluntary behavioral control suggest that alterations in frontostriatal systems contribute to higher-order repetitive behaviors in ASD.

Original languageEnglish (US)
Pages (from-to)1559-1566
Number of pages8
JournalPsychological Medicine
Volume39
Issue number9
DOIs
StatePublished - Sep 1 2009

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Keywords

  • Antisaccade
  • Neurocognition
  • Oculomotor
  • Prefrontal cortex
  • Striatum

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Mosconi, M. W., Kay, M., D'Cruz, A. M., Seidenfeld, A., Guter, S., Stanford, L. D., & Sweeney, J. A. (2009). Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders. Psychological Medicine, 39(9), 1559-1566. https://doi.org/10.1017/S0033291708004984