Impaired regional left ventricular strain after repair of tetralogy of fallot

Karen G. Ordovas, Marcus Carlsson, Katy E. Lease, Elyse Foster, Alison K. Meadows, Alastair J. Martin, Michael Hope, Loi Do, Charles B. Higgins, Maythem Saeed

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Purpose: To test the potential of magnetic resonance imaging (MRI) in early detection of left ventricular (LV) dysfunction in patients with pulmonary regurgitation and normal LV ejection fraction after repair of tetralogy of Fallot. Materials and Methods: Patients (n = 18) with repaired tetralogy of Fallot and pulmonary regurgitation were prospectively recruited. Healthy volunteers (n = 10) were used as control. Tagging MR images were acquired at the base, mid, and apical LV levels for assessing segmental rotation and circumferential strain. Cine MR images and velocity-encoded MR images were also acquired for assessment of biventricular volumes and biventricular function and pulmonary regurgitant fraction, respectively. Mean values were compared between groups using unpaired Student's t-test. Results: Patients presented with preserved global LV function (LVEF of 59 ± 5%). A significant decrease in LV peak circumferential strain was seen in patients compared with normal volunteers at the basilar (-15.6 ± 4.5% vs. -17.6 ± 4.4%; P < 0.01) and apical (-14.4± 6.1% vs. -17.3± 5.1%, P < 0.01) slices. LV peak rotation was also delayed in patients compared with volunteers at the basilar (6.1 ± 2.6° vs. 4.2 ± 0.6°; P < 0.01) and mid (8.0 ± 1.7° vs. 4.9 ± 1.0°; P < 0.01) slices. Conclusion: MRI can detect early regional LV dysfunction in patients with preserved LVEF after repair of tetralogy of Fallot. MR may be a useful technique for guiding clinical decisions in these patients in order to prevent future global LV deterioration.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume35
Issue number1
DOIs
StatePublished - Jan 2012

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Tetralogy of Fallot
Pulmonary Valve Insufficiency
Left Ventricular Dysfunction
Healthy Volunteers
Magnetic Resonance Imaging
Left Ventricular Function
Stroke Volume
Volunteers
Students
Lung

Keywords

  • left ventricle
  • MR imaging
  • strain
  • tetralogy of Fallot

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Ordovas, K. G., Carlsson, M., Lease, K. E., Foster, E., Meadows, A. K., Martin, A. J., ... Saeed, M. (2012). Impaired regional left ventricular strain after repair of tetralogy of fallot. Journal of Magnetic Resonance Imaging, 35(1), 79-85. https://doi.org/10.1002/jmri.22686

Impaired regional left ventricular strain after repair of tetralogy of fallot. / Ordovas, Karen G.; Carlsson, Marcus; Lease, Katy E.; Foster, Elyse; Meadows, Alison K.; Martin, Alastair J.; Hope, Michael; Do, Loi; Higgins, Charles B.; Saeed, Maythem.

In: Journal of Magnetic Resonance Imaging, Vol. 35, No. 1, 01.2012, p. 79-85.

Research output: Contribution to journalArticle

Ordovas, KG, Carlsson, M, Lease, KE, Foster, E, Meadows, AK, Martin, AJ, Hope, M, Do, L, Higgins, CB & Saeed, M 2012, 'Impaired regional left ventricular strain after repair of tetralogy of fallot', Journal of Magnetic Resonance Imaging, vol. 35, no. 1, pp. 79-85. https://doi.org/10.1002/jmri.22686
Ordovas, Karen G. ; Carlsson, Marcus ; Lease, Katy E. ; Foster, Elyse ; Meadows, Alison K. ; Martin, Alastair J. ; Hope, Michael ; Do, Loi ; Higgins, Charles B. ; Saeed, Maythem. / Impaired regional left ventricular strain after repair of tetralogy of fallot. In: Journal of Magnetic Resonance Imaging. 2012 ; Vol. 35, No. 1. pp. 79-85.
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abstract = "Purpose: To test the potential of magnetic resonance imaging (MRI) in early detection of left ventricular (LV) dysfunction in patients with pulmonary regurgitation and normal LV ejection fraction after repair of tetralogy of Fallot. Materials and Methods: Patients (n = 18) with repaired tetralogy of Fallot and pulmonary regurgitation were prospectively recruited. Healthy volunteers (n = 10) were used as control. Tagging MR images were acquired at the base, mid, and apical LV levels for assessing segmental rotation and circumferential strain. Cine MR images and velocity-encoded MR images were also acquired for assessment of biventricular volumes and biventricular function and pulmonary regurgitant fraction, respectively. Mean values were compared between groups using unpaired Student's t-test. Results: Patients presented with preserved global LV function (LVEF of 59 ± 5{\%}). A significant decrease in LV peak circumferential strain was seen in patients compared with normal volunteers at the basilar (-15.6 ± 4.5{\%} vs. -17.6 ± 4.4{\%}; P < 0.01) and apical (-14.4± 6.1{\%} vs. -17.3± 5.1{\%}, P < 0.01) slices. LV peak rotation was also delayed in patients compared with volunteers at the basilar (6.1 ± 2.6° vs. 4.2 ± 0.6°; P < 0.01) and mid (8.0 ± 1.7° vs. 4.9 ± 1.0°; P < 0.01) slices. Conclusion: MRI can detect early regional LV dysfunction in patients with preserved LVEF after repair of tetralogy of Fallot. MR may be a useful technique for guiding clinical decisions in these patients in order to prevent future global LV deterioration.",
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AU - Martin, Alastair J.

AU - Hope, Michael

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N2 - Purpose: To test the potential of magnetic resonance imaging (MRI) in early detection of left ventricular (LV) dysfunction in patients with pulmonary regurgitation and normal LV ejection fraction after repair of tetralogy of Fallot. Materials and Methods: Patients (n = 18) with repaired tetralogy of Fallot and pulmonary regurgitation were prospectively recruited. Healthy volunteers (n = 10) were used as control. Tagging MR images were acquired at the base, mid, and apical LV levels for assessing segmental rotation and circumferential strain. Cine MR images and velocity-encoded MR images were also acquired for assessment of biventricular volumes and biventricular function and pulmonary regurgitant fraction, respectively. Mean values were compared between groups using unpaired Student's t-test. Results: Patients presented with preserved global LV function (LVEF of 59 ± 5%). A significant decrease in LV peak circumferential strain was seen in patients compared with normal volunteers at the basilar (-15.6 ± 4.5% vs. -17.6 ± 4.4%; P < 0.01) and apical (-14.4± 6.1% vs. -17.3± 5.1%, P < 0.01) slices. LV peak rotation was also delayed in patients compared with volunteers at the basilar (6.1 ± 2.6° vs. 4.2 ± 0.6°; P < 0.01) and mid (8.0 ± 1.7° vs. 4.9 ± 1.0°; P < 0.01) slices. Conclusion: MRI can detect early regional LV dysfunction in patients with preserved LVEF after repair of tetralogy of Fallot. MR may be a useful technique for guiding clinical decisions in these patients in order to prevent future global LV deterioration.

AB - Purpose: To test the potential of magnetic resonance imaging (MRI) in early detection of left ventricular (LV) dysfunction in patients with pulmonary regurgitation and normal LV ejection fraction after repair of tetralogy of Fallot. Materials and Methods: Patients (n = 18) with repaired tetralogy of Fallot and pulmonary regurgitation were prospectively recruited. Healthy volunteers (n = 10) were used as control. Tagging MR images were acquired at the base, mid, and apical LV levels for assessing segmental rotation and circumferential strain. Cine MR images and velocity-encoded MR images were also acquired for assessment of biventricular volumes and biventricular function and pulmonary regurgitant fraction, respectively. Mean values were compared between groups using unpaired Student's t-test. Results: Patients presented with preserved global LV function (LVEF of 59 ± 5%). A significant decrease in LV peak circumferential strain was seen in patients compared with normal volunteers at the basilar (-15.6 ± 4.5% vs. -17.6 ± 4.4%; P < 0.01) and apical (-14.4± 6.1% vs. -17.3± 5.1%, P < 0.01) slices. LV peak rotation was also delayed in patients compared with volunteers at the basilar (6.1 ± 2.6° vs. 4.2 ± 0.6°; P < 0.01) and mid (8.0 ± 1.7° vs. 4.9 ± 1.0°; P < 0.01) slices. Conclusion: MRI can detect early regional LV dysfunction in patients with preserved LVEF after repair of tetralogy of Fallot. MR may be a useful technique for guiding clinical decisions in these patients in order to prevent future global LV deterioration.

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