Impairment of Hemostasis in Patients With Severe Hemophilia: Failure of Diphenhydramine, Chlorpromazine, and Guaifenesin

G. R. Buchanan, R. I. Handin

Research output: Contribution to journalArticle

4 Scopus citations


Twenty-three patients with severe hemophilia were given single or multiple doses of diphenhydramine hydrochloride, chlorpromazine hydrochloride, or guaifenesin to test their effects on hemostasis. In contrast with earlier studies with aspirin, bleeding times were not prolonged after ingestion of these three drugs. No patient had hemorrhage because of the drugs, and none recalled excessive bleeding following drug ingestion. These results greatly extend the clinical implications of prior observations carried out in normal subjects demonstrating that many antiplatelet drugs have no effects on in vivo hemostasis. We conclude that these drugs are probably safe for patients with bleeding disorders like hemophilia.

Original languageEnglish (US)
Pages (from-to)2173-2174
Number of pages2
JournalJAMA: The Journal of the American Medical Association
Issue number20
StatePublished - Nov 10 1978


ASJC Scopus subject areas

  • Medicine(all)

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