Imparting multivalency to a bifunctional chelator: A scaffold design for targeted PET imaging probes

Wei Liu, Guiyang Hao, Michael A. Long, Tiffani Anthony, Jer Tsong Hsieh, Xiankai Sun

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Two are better than one: Multivalent scaffolds for targeted PET imaging probes not only feature chelators that form stable and neutral complexes with a radiometal but also contain functional groups for presentation of multiple targeting molecules. A bivalent scaffold was synthesized and coupled with a targeting ligand to afford the probe, which was used to efficiently image tumors in vivo (see picture).

Original languageEnglish (US)
Pages (from-to)7346-7349
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number40
DOIs
StatePublished - Sep 21 2009

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Keywords

  • Chelates
  • Imaging agents
  • Multivalent effect
  • Radiochemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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