Implementation and Performance of Automated Software for Computing Right-to-Left Ventricular Diameter Ratio From Computed Tomography Pulmonary Angiography Images

Kanako K. Kumamaru, Elizabeth George, Ayaz Aghayev, Sachin S. Saboo, Ashish Khandelwal, Sara Rodríguez-López, Tianrun Cai, Daniel Jiménez-Carretero, Raúl San José Estépar, Maria J. Ledesma-Carbayo, Germán González, Frank J. Rybicki

Research output: Contribution to journalArticle

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OBJECTIVE: The aim of this study was to prospectively test the performance and potential for clinical integration of software that automatically calculates the right-to-left ventricular (RV/LV) diameter ratio from computed tomography pulmonary angiography images. METHODS: Using 115 computed tomography pulmonary angiography images that were positive for acute pulmonary embolism, we prospectively evaluated RV/LV ratio measurements that were obtained as follows: (1) completely manual measurement (reference standard), (2) completely automated measurement using the software, and (3 and 4) using a customized software interface that allowed 2 independent radiologists to manually adjust the automatically positioned calipers. RESULTS: Automated measurements underestimated (P <0.001) the reference standard (1.09 [0.25] vs1.03 [0.35]). With manual correction of the automatically positioned calipers, the mean ratio became closer to the reference standard (1.06 [0.29] by read 1 and 1.07 [0.30] by read 2), and the correlation improved (r = 0.675 to 0.872 and 0.887). The mean time required for manual adjustment (37 [20] seconds) was significantly less than the time required to perform measurements entirely manually (100 [23] seconds). CONCLUSIONS: Automated CT RV/LV diameter ratio software shows promise for integration into the clinical workflow for patients with acute pulmonary embolism.

Original languageEnglish (US)
JournalJournal of Computer Assisted Tomography
Publication statusAccepted/In press - Mar 3 2016


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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