Implementing large-scale ENU mutagenesis screens in North America

Amander T. Clark, Daniel Goldowitz, Joseph S. Takahashi, Martha Hotz Vitaterna, Sandra M. Siepka, Luanne L. Peters, Wayne N. Frankel, George A. Carlson, Janet Rossant, Joseph H. Nadeau, Monica J. Justice

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

A step towards annotating the mouse genome is to use forward genetics in phenotype-driven screens to saturate the genome with mutations. The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening.

Original languageEnglish (US)
Pages (from-to)51-64
Number of pages14
JournalGenetica
Volume122
Issue number1
DOIs
StatePublished - Sep 1 2004

Keywords

  • Human Genome Project
  • Mouse Genome Project
  • balancer chromosomes
  • mouse mutagenesis
  • phenotype screens

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics
  • Plant Science
  • Insect Science

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  • Cite this

    Clark, A. T., Goldowitz, D., Takahashi, J. S., Vitaterna, M. H., Siepka, S. M., Peters, L. L., Frankel, W. N., Carlson, G. A., Rossant, J., Nadeau, J. H., & Justice, M. J. (2004). Implementing large-scale ENU mutagenesis screens in North America. Genetica, 122(1), 51-64. https://doi.org/10.1007/s10709-004-1436-6