Improved neurologic function after long-term correction of vitamin E deficiency in children with chronic cholestasis

R. J. Sokol, M. A. Guggenheim, S. T. Iannaccone, P. E. Barkhaus, C. Miller, A. Silverman, W. F. Balistreri, J. E. Heubi

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Abstract

We studied the effect of long-term correction of vitamin E deficiency on neurologic function in 14 children with chronic cholestasis. Vitamin E repletion was achieved in all, either by large oral doses (up to 120 IU per kilogram of body weight per day) or by intramuscular administration of dl-alpha-tocopherol (0.8 to 2.0 IU per kilogram per day). With early institution of therapy, neurologic function remained normal in two asymptomatic children below the age of three years after 15 and 18 months of therapy. Neurologic function became normal in three symptomatic children below age three after 18 to 32 months of therapy. Restitution of neurologic function was more limited in nine symptomatic children 5 to 17 1/2 years old after 18 to 48 months of therapy. We conclude that vitamin E repletion therapy should be initiated at an early age in children with chronic cholestasis complicated by vitamin E deficiency, to prevent irreversible neurologic injury.

Original languageEnglish (US)
Pages (from-to)1580-1586
Number of pages7
JournalNew England Journal of Medicine
Volume313
Issue number25
StatePublished - 1985

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Vitamin E Deficiency
Cholestasis
Nervous System
Vitamin E
Nervous System Trauma
alpha-Tocopherol
Secondary Prevention
Therapeutics
Body Weight

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sokol, R. J., Guggenheim, M. A., Iannaccone, S. T., Barkhaus, P. E., Miller, C., Silverman, A., ... Heubi, J. E. (1985). Improved neurologic function after long-term correction of vitamin E deficiency in children with chronic cholestasis. New England Journal of Medicine, 313(25), 1580-1586.

Improved neurologic function after long-term correction of vitamin E deficiency in children with chronic cholestasis. / Sokol, R. J.; Guggenheim, M. A.; Iannaccone, S. T.; Barkhaus, P. E.; Miller, C.; Silverman, A.; Balistreri, W. F.; Heubi, J. E.

In: New England Journal of Medicine, Vol. 313, No. 25, 1985, p. 1580-1586.

Research output: Contribution to journalArticle

Sokol, RJ, Guggenheim, MA, Iannaccone, ST, Barkhaus, PE, Miller, C, Silverman, A, Balistreri, WF & Heubi, JE 1985, 'Improved neurologic function after long-term correction of vitamin E deficiency in children with chronic cholestasis', New England Journal of Medicine, vol. 313, no. 25, pp. 1580-1586.
Sokol, R. J. ; Guggenheim, M. A. ; Iannaccone, S. T. ; Barkhaus, P. E. ; Miller, C. ; Silverman, A. ; Balistreri, W. F. ; Heubi, J. E. / Improved neurologic function after long-term correction of vitamin E deficiency in children with chronic cholestasis. In: New England Journal of Medicine. 1985 ; Vol. 313, No. 25. pp. 1580-1586.
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