Improved quantitative contrast-enhanced ultrasound imaging of hepatocellular carcinoma response to transarterial chemoembolization

Ipek Oezdemir, Collette Shaw, John R. Eisenbrey, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

The purpose of this research project was to improve the quantification of microvascular networks depicted in contrast-enhanced ultrasound (CEUS) images of human hepatocellular carcinoma (HCC). Due to limited anatomical information in CEUS images, grayscale B-mode ultrasound (US) data is preferred when estimating tissue motion. Transformation functions derived from the B-mode data are one solution for registering a dynamic sequence of CEUS images. Microvessel density (MVD) can then be calculated from both the original and motion corrected CEUS images as the ratio of the number of contrast-enhanced image pixels with a value greater than zero to the number of pixels of the entire tumor space. Using US images of HCC before and after treatment with transarterial chemoembolization, results revealed that affine and non-rigid motion correction improves visualization and quantitative analysis of clinical data. Using the correlation coefficient (CC) between CEUS frames as metric of tissue motion, our motion correction strategy produced a 20% increase in the average CC from motion corrected frames compared to the data before correction (p \lt 0.001). Furthermore, enhanced visualization of microvascular networks in the treated liver tumor space may improve determination of treatment efficacy and need for any repeat procedures.

Original languageEnglish (US)
Title of host publicationISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages1737-1740
Number of pages4
ISBN (Electronic)9781538636411
DOIs
StatePublished - Apr 2019
Externally publishedYes
Event16th IEEE International Symposium on Biomedical Imaging, ISBI 2019 - Venice, Italy
Duration: Apr 8 2019Apr 11 2019

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2019-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Conference

Conference16th IEEE International Symposium on Biomedical Imaging, ISBI 2019
CountryItaly
CityVenice
Period4/8/194/11/19

Keywords

  • Cancer
  • Contrast-enhanced ultrasound
  • Image registration, microbubble contrast agents, microvascular networks
  • Motion correction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Oezdemir, I., Shaw, C., Eisenbrey, J. R., & Hoyt, K. (2019). Improved quantitative contrast-enhanced ultrasound imaging of hepatocellular carcinoma response to transarterial chemoembolization. In ISBI 2019 - 2019 IEEE International Symposium on Biomedical Imaging (pp. 1737-1740). [8759238] (Proceedings - International Symposium on Biomedical Imaging; Vol. 2019-April). IEEE Computer Society. https://doi.org/10.1109/ISBI.2019.8759238