Improved synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-darabinofuranosyluracil([18f]FMAU)

Zibo Li, Hancheng Cai, Peter S. Conti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

[18F]FMAU is an established PET probe used to monitor cellular proliferation. For clinical applications, a fully automated cGMP-compliant radiosynthesis would be preferred. However, the current synthesis of [18F]FMAU requires HBr activation of the sugar prior to the coupling with silylated uracil. This multiple step procedure makes the development of an automated protocol difficult and complicated. In this study, we report the use of Friedel-Crafts catalysts for an improved synthesis of [18F]FMAU, which also includes a significantly simplified one-pot reaction condition.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalCurrent Radiopharmaceuticals
Volume4
Issue number1
DOIs
StatePublished - Jun 2011

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Uracil
Cell Proliferation
Clevudine

Keywords

  • [F]FMAU
  • Cellular proliferation
  • Friedel-crafts catalysts
  • PET probe
  • Radiosynthesis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pharmacology

Cite this

Improved synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-darabinofuranosyluracil([18f]FMAU). / Li, Zibo; Cai, Hancheng; Conti, Peter S.

In: Current Radiopharmaceuticals, Vol. 4, No. 1, 06.2011, p. 24-30.

Research output: Contribution to journalArticle

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