Improved Yields of Iodine-124 from the Enriched Tellurium-124 Dioxide/Aluminum Oxide Target

R. D. Finn, J. Qiao, A. Nacca, Y. Sheh, C. Lom, J. Balatoni, S. Cai, W. Bornmann, K. Pentlow

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The escalating clinical application of Positron Emission Tomography results from the novel radiotracers which are available to monitor specific biochemical or physiologic processes. Future developments of the technique will require an increasing availability of additional unique radioligands and radionuclides. Iodine-124, a radionuclide whose potential for both diagnostic and therapeutic applications is widely recognized, has been prepared at Memorial Sloan-Kettering Cancer Center on a weekly basis for several years (1). With its characteristic 4.18 day half life and complex decay scheme (2) which includes positron emission (22.0 ± 0.5%) and electron capture (78 ± 0.5%), this radionuclide has been shown to be appropriate for radiotracers describing slow physiologic processes with the clearance of non-specific radioactivity. The refinements and modifications being engineered into the cyclotron target system to increase the absolute yield of recoverable radioactivity from each irradiation and its chemical processing of the reusable solid target matrix are described.

Original languageEnglish (US)
Title of host publicationApplication of Accelerators in Research and Industry
Subtitle of host publication17th International Conference on the Application of Accelerators in Research and Industry
EditorsJerome L. Duggan, Margaret Hall, Ira Lon Morgan
PublisherAmerican Institute of Physics Inc.
Pages1121-1124
Number of pages4
ISBN (Electronic)0735401497
DOIs
StatePublished - Aug 26 2003
Externally publishedYes
Event17th International Conference on the Application of Accelerators in Research and Industry - Denton, United States
Duration: Nov 12 2002Nov 16 2002

Publication series

NameAIP Conference Proceedings
Volume680
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other17th International Conference on the Application of Accelerators in Research and Industry
CountryUnited States
CityDenton
Period11/12/0211/16/02

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Finn, R. D., Qiao, J., Nacca, A., Sheh, Y., Lom, C., Balatoni, J., Cai, S., Bornmann, W., & Pentlow, K. (2003). Improved Yields of Iodine-124 from the Enriched Tellurium-124 Dioxide/Aluminum Oxide Target. In J. L. Duggan, M. Hall, & I. L. Morgan (Eds.), Application of Accelerators in Research and Industry: 17th International Conference on the Application of Accelerators in Research and Industry (pp. 1121-1124). (AIP Conference Proceedings; Vol. 680). American Institute of Physics Inc.. https://doi.org/10.1063/1.1619905