Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients

Maria Bano, Usama B. Kanaan, Alexandra C. Ehrlich, Courtney McCracken, Gemma Morrow, Matthew E. Oster, Ritu Sachdeva

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background Tricuspid annular plane systolic excursion (TAPSE) has emerged as a novel and reliable measure of right ventricular (RV) function. The purpose of this study was to determine the effect of pulmonary hypertension (PH) therapy on TAPSE in pediatric patients and compare TAPSE to other quantitative measures of RV function. Methods A retrospective review of medical records and echocardiograms of patients in the PH clinic from January 2011 to August 2013 was done. Echocardiograms were analyzed prior to initiation or addition of a PH drug and at least 8 weeks later. Following quantitative measures of RV function were compared: TAPSE, TAPSE age-based z-score, RV fractional area change (RVFAC), tricuspid annular S′, tricuspid inflow E/tricuspid annular E′ velocity (TV E/E′), and RV myocardial performance index (RVMPI). Results Of the 37 patients included in this study (median age 0.6 years), 23 (62.2%) were treatment naive and others had a new PH drug added to their regimen at the time of the baseline echocardiogram. The median duration between the baseline and follow-up echocardiogram was 8 (2-25) months. There was a significant improvement in TAPSE and TAPSE age-based z-score on the follow-up echocardiogram. RVFAC, tricuspid S′, TV E/E′, and RVMPI did not show a statistically significant change. Conclusion In contrast to the other echocardiographic markers of RV function, TAPSE, and TAPSE age-based z-score significantly improve after initiation or addition of PH therapy and can be used for serial noninvasive monitoring of RV function in pediatric PH patients.

Original languageEnglish (US)
Pages (from-to)1228-1232
Number of pages5
JournalEchocardiography
Volume32
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Right Ventricular Function
Pulmonary Hypertension
Pediatrics
Therapeutics
Pharmaceutical Preparations
Medical Records

Keywords

  • pulmonary hypertension
  • tissue Doppler echocardiography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Bano, M., Kanaan, U. B., Ehrlich, A. C., McCracken, C., Morrow, G., Oster, M. E., & Sachdeva, R. (2015). Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients. Echocardiography, 32(8), 1228-1232. https://doi.org/10.1111/echo.12835

Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients. / Bano, Maria; Kanaan, Usama B.; Ehrlich, Alexandra C.; McCracken, Courtney; Morrow, Gemma; Oster, Matthew E.; Sachdeva, Ritu.

In: Echocardiography, Vol. 32, No. 8, 01.08.2015, p. 1228-1232.

Research output: Contribution to journalArticle

Bano, M, Kanaan, UB, Ehrlich, AC, McCracken, C, Morrow, G, Oster, ME & Sachdeva, R 2015, 'Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients', Echocardiography, vol. 32, no. 8, pp. 1228-1232. https://doi.org/10.1111/echo.12835
Bano, Maria ; Kanaan, Usama B. ; Ehrlich, Alexandra C. ; McCracken, Courtney ; Morrow, Gemma ; Oster, Matthew E. ; Sachdeva, Ritu. / Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients. In: Echocardiography. 2015 ; Vol. 32, No. 8. pp. 1228-1232.
@article{164404f74ad44a53a1f4164aa7f79220,
title = "Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients",
abstract = "Background Tricuspid annular plane systolic excursion (TAPSE) has emerged as a novel and reliable measure of right ventricular (RV) function. The purpose of this study was to determine the effect of pulmonary hypertension (PH) therapy on TAPSE in pediatric patients and compare TAPSE to other quantitative measures of RV function. Methods A retrospective review of medical records and echocardiograms of patients in the PH clinic from January 2011 to August 2013 was done. Echocardiograms were analyzed prior to initiation or addition of a PH drug and at least 8 weeks later. Following quantitative measures of RV function were compared: TAPSE, TAPSE age-based z-score, RV fractional area change (RVFAC), tricuspid annular S′, tricuspid inflow E/tricuspid annular E′ velocity (TV E/E′), and RV myocardial performance index (RVMPI). Results Of the 37 patients included in this study (median age 0.6 years), 23 (62.2{\%}) were treatment naive and others had a new PH drug added to their regimen at the time of the baseline echocardiogram. The median duration between the baseline and follow-up echocardiogram was 8 (2-25) months. There was a significant improvement in TAPSE and TAPSE age-based z-score on the follow-up echocardiogram. RVFAC, tricuspid S′, TV E/E′, and RVMPI did not show a statistically significant change. Conclusion In contrast to the other echocardiographic markers of RV function, TAPSE, and TAPSE age-based z-score significantly improve after initiation or addition of PH therapy and can be used for serial noninvasive monitoring of RV function in pediatric PH patients.",
keywords = "pulmonary hypertension, tissue Doppler echocardiography",
author = "Maria Bano and Kanaan, {Usama B.} and Ehrlich, {Alexandra C.} and Courtney McCracken and Gemma Morrow and Oster, {Matthew E.} and Ritu Sachdeva",
year = "2015",
month = "8",
day = "1",
doi = "10.1111/echo.12835",
language = "English (US)",
volume = "32",
pages = "1228--1232",
journal = "Echocardiography",
issn = "0742-2822",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients

AU - Bano, Maria

AU - Kanaan, Usama B.

AU - Ehrlich, Alexandra C.

AU - McCracken, Courtney

AU - Morrow, Gemma

AU - Oster, Matthew E.

AU - Sachdeva, Ritu

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Background Tricuspid annular plane systolic excursion (TAPSE) has emerged as a novel and reliable measure of right ventricular (RV) function. The purpose of this study was to determine the effect of pulmonary hypertension (PH) therapy on TAPSE in pediatric patients and compare TAPSE to other quantitative measures of RV function. Methods A retrospective review of medical records and echocardiograms of patients in the PH clinic from January 2011 to August 2013 was done. Echocardiograms were analyzed prior to initiation or addition of a PH drug and at least 8 weeks later. Following quantitative measures of RV function were compared: TAPSE, TAPSE age-based z-score, RV fractional area change (RVFAC), tricuspid annular S′, tricuspid inflow E/tricuspid annular E′ velocity (TV E/E′), and RV myocardial performance index (RVMPI). Results Of the 37 patients included in this study (median age 0.6 years), 23 (62.2%) were treatment naive and others had a new PH drug added to their regimen at the time of the baseline echocardiogram. The median duration between the baseline and follow-up echocardiogram was 8 (2-25) months. There was a significant improvement in TAPSE and TAPSE age-based z-score on the follow-up echocardiogram. RVFAC, tricuspid S′, TV E/E′, and RVMPI did not show a statistically significant change. Conclusion In contrast to the other echocardiographic markers of RV function, TAPSE, and TAPSE age-based z-score significantly improve after initiation or addition of PH therapy and can be used for serial noninvasive monitoring of RV function in pediatric PH patients.

AB - Background Tricuspid annular plane systolic excursion (TAPSE) has emerged as a novel and reliable measure of right ventricular (RV) function. The purpose of this study was to determine the effect of pulmonary hypertension (PH) therapy on TAPSE in pediatric patients and compare TAPSE to other quantitative measures of RV function. Methods A retrospective review of medical records and echocardiograms of patients in the PH clinic from January 2011 to August 2013 was done. Echocardiograms were analyzed prior to initiation or addition of a PH drug and at least 8 weeks later. Following quantitative measures of RV function were compared: TAPSE, TAPSE age-based z-score, RV fractional area change (RVFAC), tricuspid annular S′, tricuspid inflow E/tricuspid annular E′ velocity (TV E/E′), and RV myocardial performance index (RVMPI). Results Of the 37 patients included in this study (median age 0.6 years), 23 (62.2%) were treatment naive and others had a new PH drug added to their regimen at the time of the baseline echocardiogram. The median duration between the baseline and follow-up echocardiogram was 8 (2-25) months. There was a significant improvement in TAPSE and TAPSE age-based z-score on the follow-up echocardiogram. RVFAC, tricuspid S′, TV E/E′, and RVMPI did not show a statistically significant change. Conclusion In contrast to the other echocardiographic markers of RV function, TAPSE, and TAPSE age-based z-score significantly improve after initiation or addition of PH therapy and can be used for serial noninvasive monitoring of RV function in pediatric PH patients.

KW - pulmonary hypertension

KW - tissue Doppler echocardiography

UR - http://www.scopus.com/inward/record.url?scp=84937524174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937524174&partnerID=8YFLogxK

U2 - 10.1111/echo.12835

DO - 10.1111/echo.12835

M3 - Article

VL - 32

SP - 1228

EP - 1232

JO - Echocardiography

JF - Echocardiography

SN - 0742-2822

IS - 8

ER -