### Abstract

The sensitivity of indicator dilution measurement of capillary perfusion rate to errors in the experimental variables was studied. Parameter sensitivity analysis and models based on a diffusion equation with a capillary-level convection term were used. The sensitivity analysis is based on normalized partial derivatives of indicator concentration with respect to experimental variables (time, position, etc. ). Results for washout models commonly employed in flow analysis produced some striking findings. The sensitivity of a perfusion estimate to errors in measured indicator concentration is orders of magnitude higher than it is to other variables in the material balance. The best estimate of perfusion can be shown to occur at predictable times in the washout period. Those variables yielding the highest sensitivity to error in the perfusion estimate can be identified in this manner and the protocol designed accordingly to minimize that error.

Original language | English (US) |
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Title of host publication | Computers in Cardiology |

Publisher | IEEE |

Pages | 471-474 |

Number of pages | 4 |

State | Published - 1980 |

Event | Unknown conference - Williamsburg, VA, USA Duration: Oct 22 1980 → Oct 24 1980 |

### Other

Other | Unknown conference |
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City | Williamsburg, VA, USA |

Period | 10/22/80 → 10/24/80 |

### Fingerprint

### ASJC Scopus subject areas

- Software
- Cardiology and Cardiovascular Medicine

### Cite this

*Computers in Cardiology*(pp. 471-474). IEEE.

**IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS.** / Shitzer, Avraham; Eberhart, Robert; Eisenfeld, Jerome.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

*Computers in Cardiology.*IEEE, pp. 471-474, Unknown conference, Williamsburg, VA, USA, 10/22/80.

}

TY - CHAP

T1 - IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS.

AU - Shitzer, Avraham

AU - Eberhart, Robert

AU - Eisenfeld, Jerome

PY - 1980

Y1 - 1980

N2 - The sensitivity of indicator dilution measurement of capillary perfusion rate to errors in the experimental variables was studied. Parameter sensitivity analysis and models based on a diffusion equation with a capillary-level convection term were used. The sensitivity analysis is based on normalized partial derivatives of indicator concentration with respect to experimental variables (time, position, etc. ). Results for washout models commonly employed in flow analysis produced some striking findings. The sensitivity of a perfusion estimate to errors in measured indicator concentration is orders of magnitude higher than it is to other variables in the material balance. The best estimate of perfusion can be shown to occur at predictable times in the washout period. Those variables yielding the highest sensitivity to error in the perfusion estimate can be identified in this manner and the protocol designed accordingly to minimize that error.

AB - The sensitivity of indicator dilution measurement of capillary perfusion rate to errors in the experimental variables was studied. Parameter sensitivity analysis and models based on a diffusion equation with a capillary-level convection term were used. The sensitivity analysis is based on normalized partial derivatives of indicator concentration with respect to experimental variables (time, position, etc. ). Results for washout models commonly employed in flow analysis produced some striking findings. The sensitivity of a perfusion estimate to errors in measured indicator concentration is orders of magnitude higher than it is to other variables in the material balance. The best estimate of perfusion can be shown to occur at predictable times in the washout period. Those variables yielding the highest sensitivity to error in the perfusion estimate can be identified in this manner and the protocol designed accordingly to minimize that error.

UR - http://www.scopus.com/inward/record.url?scp=0019244733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019244733&partnerID=8YFLogxK

M3 - Chapter

SP - 471

EP - 474

BT - Computers in Cardiology

PB - IEEE

ER -