IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS.

Avraham Shitzer, Robert Eberhart, Jerome Eisenfeld

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The sensitivity of indicator dilution measurement of capillary perfusion rate to errors in the experimental variables was studied. Parameter sensitivity analysis and models based on a diffusion equation with a capillary-level convection term were used. The sensitivity analysis is based on normalized partial derivatives of indicator concentration with respect to experimental variables (time, position, etc. ). Results for washout models commonly employed in flow analysis produced some striking findings. The sensitivity of a perfusion estimate to errors in measured indicator concentration is orders of magnitude higher than it is to other variables in the material balance. The best estimate of perfusion can be shown to occur at predictable times in the washout period. Those variables yielding the highest sensitivity to error in the perfusion estimate can be identified in this manner and the protocol designed accordingly to minimize that error.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherIEEE
Pages471-474
Number of pages4
StatePublished - 1980
EventUnknown conference - Williamsburg, VA, USA
Duration: Oct 22 1980Oct 24 1980

Other

OtherUnknown conference
CityWilliamsburg, VA, USA
Period10/22/8010/24/80

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Capillary flow
Dilution
Sensitivity analysis
Perfusion
Convection
Derivatives

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Shitzer, A., Eberhart, R., & Eisenfeld, J. (1980). IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS. In Computers in Cardiology (pp. 471-474). IEEE.

IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS. / Shitzer, Avraham; Eberhart, Robert; Eisenfeld, Jerome.

Computers in Cardiology. IEEE, 1980. p. 471-474.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shitzer, A, Eberhart, R & Eisenfeld, J 1980, IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS. in Computers in Cardiology. IEEE, pp. 471-474, Unknown conference, Williamsburg, VA, USA, 10/22/80.
Shitzer A, Eberhart R, Eisenfeld J. IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS. In Computers in Cardiology. IEEE. 1980. p. 471-474
Shitzer, Avraham ; Eberhart, Robert ; Eisenfeld, Jerome. / IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS. Computers in Cardiology. IEEE, 1980. pp. 471-474
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