Abstract
The sensitivity of indicator dilution measurement of capillary perfusion rate to errors in the experimental variables was studied. Parameter sensitivity analysis and models based on a diffusion equation with a capillary-level convection term were used. The sensitivity analysis is based on normalized partial derivatives of indicator concentration with respect to experimental variables (time, position, etc. ). Results for washout models commonly employed in flow analysis produced some striking findings. The sensitivity of a perfusion estimate to errors in measured indicator concentration is orders of magnitude higher than it is to other variables in the material balance. The best estimate of perfusion can be shown to occur at predictable times in the washout period. Those variables yielding the highest sensitivity to error in the perfusion estimate can be identified in this manner and the protocol designed accordingly to minimize that error.
| Original language | English (US) |
|---|---|
| Title of host publication | Computers in Cardiology |
| Publisher | IEEE |
| Pages | 471-474 |
| Number of pages | 4 |
| State | Published - 1980 |
| Event | Unknown conference - Williamsburg, VA, USA Duration: Oct 22 1980 → Oct 24 1980 |
Other
| Other | Unknown conference |
|---|---|
| City | Williamsburg, VA, USA |
| Period | 10/22/80 → 10/24/80 |
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ASJC Scopus subject areas
- Software
- Cardiology and Cardiovascular Medicine
Cite this
IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS. / Shitzer, Avraham; Eberhart, Robert; Eisenfeld, Jerome.
Computers in Cardiology. IEEE, 1980. p. 471-474.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - IMPROVEMENT OF INDICATOR DILUTION-BASED CAPILLARY FLOW ESTIMATION BY SENSITIVITY ANALYSIS.
AU - Shitzer, Avraham
AU - Eberhart, Robert
AU - Eisenfeld, Jerome
PY - 1980
Y1 - 1980
N2 - The sensitivity of indicator dilution measurement of capillary perfusion rate to errors in the experimental variables was studied. Parameter sensitivity analysis and models based on a diffusion equation with a capillary-level convection term were used. The sensitivity analysis is based on normalized partial derivatives of indicator concentration with respect to experimental variables (time, position, etc. ). Results for washout models commonly employed in flow analysis produced some striking findings. The sensitivity of a perfusion estimate to errors in measured indicator concentration is orders of magnitude higher than it is to other variables in the material balance. The best estimate of perfusion can be shown to occur at predictable times in the washout period. Those variables yielding the highest sensitivity to error in the perfusion estimate can be identified in this manner and the protocol designed accordingly to minimize that error.
AB - The sensitivity of indicator dilution measurement of capillary perfusion rate to errors in the experimental variables was studied. Parameter sensitivity analysis and models based on a diffusion equation with a capillary-level convection term were used. The sensitivity analysis is based on normalized partial derivatives of indicator concentration with respect to experimental variables (time, position, etc. ). Results for washout models commonly employed in flow analysis produced some striking findings. The sensitivity of a perfusion estimate to errors in measured indicator concentration is orders of magnitude higher than it is to other variables in the material balance. The best estimate of perfusion can be shown to occur at predictable times in the washout period. Those variables yielding the highest sensitivity to error in the perfusion estimate can be identified in this manner and the protocol designed accordingly to minimize that error.
UR - http://www.scopus.com/inward/record.url?scp=0019244733&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019244733&partnerID=8YFLogxK
M3 - Chapter
SP - 471
EP - 474
BT - Computers in Cardiology
PB - IEEE
ER -