Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics

H. Hidaka, M. Nagulesparan, I. Klimes, R. Clark, H. Sasaki, S. L. Aronoff, B. Vasquez, A. H. Rubenstein, Roger H Unger

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Insulin secretion and insulin resistance were examined in seven obese type II diabetics before and after control of plasma glucose levels without weight loss. Control was achieved by regular insulin injection (60-205 U/day in four doses). After 10 days of therapy, plasma insulin and C-peptide responses to oral glucose were significantly improved. Insulininduced glucose disposal rates, estimated by the glucose clamp technique, averaged 1.08 ± 0.30 mg/kg-min (mean ± SEM; n = 7) before treatment and were unchanged (1.08 ± 0.25) after treatment. These results indicate that short term control of plasma glucose improved insulin secretion but not insulin sensitivity. The impaired insulin secretion and insulin sensitivity in type II diabetics appears to be, in part, secondary to metabolic abnormalities associated with hyperglycemia.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume54
Issue number2
DOIs
StatePublished - 1982

Fingerprint

Insulin Resistance
Insulin
Plasmas
Glucose
Glucose Clamp Technique
C-Peptide
Hyperglycemia
Weight Loss
Therapeutics
Clamping devices
Injections
Scanning electron microscopy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics. / Hidaka, H.; Nagulesparan, M.; Klimes, I.; Clark, R.; Sasaki, H.; Aronoff, S. L.; Vasquez, B.; Rubenstein, A. H.; Unger, Roger H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 54, No. 2, 1982, p. 173-176.

Research output: Contribution to journalArticle

Hidaka, H. ; Nagulesparan, M. ; Klimes, I. ; Clark, R. ; Sasaki, H. ; Aronoff, S. L. ; Vasquez, B. ; Rubenstein, A. H. ; Unger, Roger H. / Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics. In: Journal of Clinical Endocrinology and Metabolism. 1982 ; Vol. 54, No. 2. pp. 173-176.
@article{a64284696afc493080e95e1266da46ff,
title = "Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics",
abstract = "Insulin secretion and insulin resistance were examined in seven obese type II diabetics before and after control of plasma glucose levels without weight loss. Control was achieved by regular insulin injection (60-205 U/day in four doses). After 10 days of therapy, plasma insulin and C-peptide responses to oral glucose were significantly improved. Insulininduced glucose disposal rates, estimated by the glucose clamp technique, averaged 1.08 ± 0.30 mg/kg-min (mean ± SEM; n = 7) before treatment and were unchanged (1.08 ± 0.25) after treatment. These results indicate that short term control of plasma glucose improved insulin secretion but not insulin sensitivity. The impaired insulin secretion and insulin sensitivity in type II diabetics appears to be, in part, secondary to metabolic abnormalities associated with hyperglycemia.",
author = "H. Hidaka and M. Nagulesparan and I. Klimes and R. Clark and H. Sasaki and Aronoff, {S. L.} and B. Vasquez and Rubenstein, {A. H.} and Unger, {Roger H}",
year = "1982",
doi = "10.1210/jcem-54-2-217",
language = "English (US)",
volume = "54",
pages = "173--176",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "2",

}

TY - JOUR

T1 - Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics

AU - Hidaka, H.

AU - Nagulesparan, M.

AU - Klimes, I.

AU - Clark, R.

AU - Sasaki, H.

AU - Aronoff, S. L.

AU - Vasquez, B.

AU - Rubenstein, A. H.

AU - Unger, Roger H

PY - 1982

Y1 - 1982

N2 - Insulin secretion and insulin resistance were examined in seven obese type II diabetics before and after control of plasma glucose levels without weight loss. Control was achieved by regular insulin injection (60-205 U/day in four doses). After 10 days of therapy, plasma insulin and C-peptide responses to oral glucose were significantly improved. Insulininduced glucose disposal rates, estimated by the glucose clamp technique, averaged 1.08 ± 0.30 mg/kg-min (mean ± SEM; n = 7) before treatment and were unchanged (1.08 ± 0.25) after treatment. These results indicate that short term control of plasma glucose improved insulin secretion but not insulin sensitivity. The impaired insulin secretion and insulin sensitivity in type II diabetics appears to be, in part, secondary to metabolic abnormalities associated with hyperglycemia.

AB - Insulin secretion and insulin resistance were examined in seven obese type II diabetics before and after control of plasma glucose levels without weight loss. Control was achieved by regular insulin injection (60-205 U/day in four doses). After 10 days of therapy, plasma insulin and C-peptide responses to oral glucose were significantly improved. Insulininduced glucose disposal rates, estimated by the glucose clamp technique, averaged 1.08 ± 0.30 mg/kg-min (mean ± SEM; n = 7) before treatment and were unchanged (1.08 ± 0.25) after treatment. These results indicate that short term control of plasma glucose improved insulin secretion but not insulin sensitivity. The impaired insulin secretion and insulin sensitivity in type II diabetics appears to be, in part, secondary to metabolic abnormalities associated with hyperglycemia.

UR - http://www.scopus.com/inward/record.url?scp=84995870920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84995870920&partnerID=8YFLogxK

U2 - 10.1210/jcem-54-2-217

DO - 10.1210/jcem-54-2-217

M3 - Article

C2 - 7033272

AN - SCOPUS:0019942238

VL - 54

SP - 173

EP - 176

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

ER -