Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics

H. Hidaka, M. Nagulesparan, I. Klimes, R. Clark, H. Sasaki, S. L. Aronoff, B. Vasquez, A. H. Rubenstein, Roger H Unger

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Insulin secretion and insulin resistance were examined in seven obese type II diabetics before and after control of plasma glucose levels without weight loss. Control was achieved by regular insulin injection (60-205 U/day in four doses). After 10 days of therapy, plasma insulin and C-peptide responses to oral glucose were significantly improved. Insulin-induced glucose disposal rates, estimated by the glucose clamp technique, averaged 1.08 ± 0.30 mg/kg.min (mean ± SEM; n = 7) before treatment and were unchanged (1.08 ± 0.25) after treatment. These results indicate that short term control of plasma glucose improved insulin secretion but not insulin sensitivity. The impaired insulin secretion and insulin sensitivity in type II diabetics appears to be, in part, secondary to metabolic abnormalities associated with hyperglycemia.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalUnknown Journal
Volume54
Issue number2
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics'. Together they form a unique fingerprint.

  • Cite this

    Hidaka, H., Nagulesparan, M., Klimes, I., Clark, R., Sasaki, H., Aronoff, S. L., Vasquez, B., Rubenstein, A. H., & Unger, R. H. (1982). Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics. Unknown Journal, 54(2), 217-222. https://doi.org/10.1210/jcem-54-2-217