Improvements in Left Ventricular Diastolic Mechanics After Parachute Device Implantation in Patients With Ischemia Heart Failure: A Cardiac Computerized Tomographic Study

Chun Ho Yun, Jing Yi Sun, Barry Templin, Shih Hsuan Lin, Kuan Ming Chen, Tung Hsin Wu, Chung Lieh Hung, Chun Chieh Liu, Hsi Hsien Hsu, Mohamad Amer Alaiti, Anas Fares, Anthony DeCicco, Hiram G. Bezerra

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background Percutaneous ventricular restoration therapy with the use of a left ventricle (LV)–partitioning Parachute device has emerged as a clinical treatment option for LV apical aneurysm after extensive anterior myocardial infarction (AMI). We assessed changes of diastolic mechanics and functional improvements following LV Parachute device implantation by means of cardiac computerized tomography (CCT). Methods and Results CCT data were obtained from 28 patients before and after LV Parachute device implantation. Diastolic functional indices were determined by means of quantitative CCT assessment: 1) transmitral velocities in early (E) and late (A) diastole and ratio (E/A); 2) early diastolic mitral septal tissue velocity (Ea) and E/Ea; and 3) vortex formation time (VFT). Functional improvements were assessed with the use of New York Heart Association (NYHA) functional classification. Among the study patients, there were no significant differences in all transmitral velocities and E/A, though there was significantly increased Ea, reduced E/Ea, and greater VFT 6 months after LV Parachute device implantation. Finally, the improvement of diastolic functional indices after Parachute treatment correlated with observed clinical functional alterations (Δ E/Ea and Δ NYHA functional class:, r = 0.563; P = .002; Δ VFT and Δ NYHA functional class: r = −0.507; P = .006). Conclusions LV Parachute device implantation therapy in heart failure caused by AMI and LV apical aneurysm formation showed improvements in several diastolic functional mechanics according to CCT-based measures.

Original languageEnglish (US)
Pages (from-to)455-463
Number of pages9
JournalJournal of Cardiac Failure
Volume23
Issue number6
DOIs
StatePublished - Jun 2017
Externally publishedYes

Keywords

  • computer tomography
  • diastolic function
  • heart failure
  • Parachute

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Yun, C. H., Sun, J. Y., Templin, B., Lin, S. H., Chen, K. M., Wu, T. H., Hung, C. L., Liu, C. C., Hsu, H. H., Alaiti, M. A., Fares, A., DeCicco, A., & Bezerra, H. G. (2017). Improvements in Left Ventricular Diastolic Mechanics After Parachute Device Implantation in Patients With Ischemia Heart Failure: A Cardiac Computerized Tomographic Study. Journal of Cardiac Failure, 23(6), 455-463. https://doi.org/10.1016/j.cardfail.2017.04.011