Improving optical contact for functional near-infrared brain spectroscopy and imaging with brush optodes

Bilal Khan, Chester Wildey, Robert Francis, Fenghua Tian, Mauricio R. Delgado, Hanli Liu, Duncan Macfarlane, George Alexandrakis

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A novel brush optode was designed and demonstrated to overcome poor optical contact with the scalp that can occur during functional near infrared spectroscopy (fNIRS) and imaging due to light obstruction by hair. The brush optodes were implemented as an attachment to existing commercial flat-faced (conventional) fiber bundle optodes. The goal was that the brush optodes would thread through hair and improve optical contact on subjects with dense hair. Simulations and experiments were performed to assess the magnitude of these improvements. FNIRS measurements on 17 subjects with varying hair colors (blonde, brown, and black) and hair densities (0-2.96 hairs/mm2) were performed during a finger tapping protocol for both flat and brush optodes. In addition to reaching a study success rate of almost 100% when using the brush optode extensions, the measurement setup times were reduced by a factor of three. Furthermore, the brush optodes enabled improvements in the activation signal-to-noise ratio (SNR) by up to a factor of ten as well as significant (p < 0.05) increases in the detected area of activation (dAoA). The measured improvements in SNR were matched by Monte Carlo (MC) simulations of photon propagation through scalp and hair. In addition, an analytical model was derived to mathematically estimate the observed light power losses due to different hair colors and hair densities. Interestingly, the derived analytical formula produced excellent estimates of the experimental data and MC simulation results despite several simplifying assumptions. The analytical model enables researchers to readily estimate the light power losses due to obstruction by hair for both flat-faced fiber bundles and individual fibers for a given subject.

Original languageEnglish (US)
Pages (from-to)878-898
Number of pages21
JournalBiomedical Optics Express
Volume3
Issue number5
DOIs
StatePublished - May 1 2012

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Near-Infrared Spectroscopy
hair
brushes
Hair Color
Neuroimaging
brain
Signal-To-Noise Ratio
Scalp
Light
spectroscopy
Photons
Fingers
Research Personnel
power loss
bundles
fibers
signal to noise ratios
estimates
activation
color

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Improving optical contact for functional near-infrared brain spectroscopy and imaging with brush optodes. / Khan, Bilal; Wildey, Chester; Francis, Robert; Tian, Fenghua; Delgado, Mauricio R.; Liu, Hanli; Macfarlane, Duncan; Alexandrakis, George.

In: Biomedical Optics Express, Vol. 3, No. 5, 01.05.2012, p. 878-898.

Research output: Contribution to journalArticle

Khan, B, Wildey, C, Francis, R, Tian, F, Delgado, MR, Liu, H, Macfarlane, D & Alexandrakis, G 2012, 'Improving optical contact for functional near-infrared brain spectroscopy and imaging with brush optodes', Biomedical Optics Express, vol. 3, no. 5, pp. 878-898. https://doi.org/10.1364/BOE.3.000878
Khan, Bilal ; Wildey, Chester ; Francis, Robert ; Tian, Fenghua ; Delgado, Mauricio R. ; Liu, Hanli ; Macfarlane, Duncan ; Alexandrakis, George. / Improving optical contact for functional near-infrared brain spectroscopy and imaging with brush optodes. In: Biomedical Optics Express. 2012 ; Vol. 3, No. 5. pp. 878-898.
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