@article{95a21abcc7464037b7dc4e65e8aff4de,
title = "Improving pain management and long-term outcomes following high-energy orthopaedic trauma (pain study)",
abstract = "Poor pain control after orthopaedic trauma is a predictor of physical disability and numerous negative long-term outcomes. Despite increased awareness of the negative consequences of poorly controlled pain, analgesic therapy among hospitalized patients after orthopaedic trauma remains inconsistent and often inadequate. The Pain study is a 3 armed, prospective, double-blind, multicenter randomized trial designed to evaluate the effect of standard pain management versus standard pain management plus perioperative nonsteroidal anti-inflammatory drugs or pregabalin in patients of ages 18-85 with extremity fractures. The primary outcomes are chronic pain, opioid utilization during the 48 hours after definitive fixation and surgery for nonunion in the year after fixation. Secondary outcomes include preoperative and postoperative pain intensity, adverse events and complications, physical function, depression, and post-traumatic stress disorder. One year treatment costs are also compared between the groups.",
keywords = "Nonunion, Opioids, Pain management, Randomized trial",
author = "METRC and Castillo, {Renan C.} and Raja, {S. N.} and Frey, {Katherine P.} and Vallier, {Heather A.} and Paul Tornetta and Todd Jaeblon and Goff, {Brandon J.} and Allan Gottschalk and Scharfstein, {Daniel O.} and O'Toole, {Robert V.} and Heather Silva and Hope Carlisle and Bosse, {Michael J.} and Christine Churchill and Hsu, {Joseph R.} and Karunakar, {Madhav A.} and Seymour, {Rachel B.} and Sims, {Stephen H.} and Jones, {Clifford B.} and Sietsema, {Debra L.} and Anglen, {Jeffrey O.} and Ertl, {Janos P.} and Mullis, {Brian H.} and Shively, {Karl D.} and Schmidt, {Andrew H.} and Mirick, {Gudrun E.} and Westberg, {Jerald R.} and Massimo Morandi and Smith, {Christopher S.} and Crickard, {Colin V.} and Daniel Connelly and Costales, {Timothy G.} and Yasmin Degani and Marinos, {Dimitrius P.} and Mascarenhas, {Daniel C.} and Reahl, {George B.} and Slobogean, {Gerard P.} and Zych, {Gabriela M.} and Zych, {Gregory A.} and Gary, {Joshua L.} and Kathy Franco and Galpin, {Matthew C.} and Harvin, {William H.} and Jaideep Mehta and Michael Willey and Tarkin, {Ivan S.} and Sathy, {Ashoke K.} and Daniel, {Cindy G.} and Obremskey, {William T.} and Archer, {Kristin R.}",
note = "Publisher Copyright: Copyright {\textcopyright} 2017 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2017",
doi = "10.1097/BOT.0000000000000793",
language = "English (US)",
volume = "31",
pages = "S71--S77",
journal = "Journal of orthopaedic trauma",
issn = "0890-5339",
publisher = "Lippincott Williams and Wilkins",
}