In myofibroblastic sarcomas of the head and neck, mitotic activity and necrosis define grade: A case study and literature review

Chunyu Cai, Louis P. Dehner, Samir K. El-Mofty

Research output: Contribution to journalArticle

8 Scopus citations


Low-grade myofibroblastic sarcoma (LGMFS) is considered a distinct entity in the World Health Organization classification of soft tissue neoplasms, defined as an atypical myofibroblastic proliferation with fibromatosis-like features and a predilection for the head and neck. A substantial subset of previously reported myofibroblastic sarcomas (MFS), particularly in the head and neck region, are associated with appreciable tumor-associated morbidity and mortality and should be differentiated from the more indolent LGMFS. However, no specific morphological criteria have been developed to define the entity of LGMFS. We have reviewed histological findings in conjunction with clinical follow-up information of previously reported MFS in the head and neck region in the English literature, with the addition of five new cases from our institution. We found that MFSs with 6 or more mitoses per 10 high power fields and/or presence of spontaneous necrosis were accompanied by a higher mortality rate that is statistically significant.

Original languageEnglish (US)
Pages (from-to)827-836
Number of pages10
JournalVirchows Archiv
Issue number6
StatePublished - Dec 2013



  • Head and neck
  • Low-grade myofibroblastic sarcoma
  • Myofibroblastic sarcoma
  • Pleomorphic myofibrosarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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