In vitro and in vivo assessment of CdTe and CdHgTe toxicity and clearance

Li Liu, Jun Zhang, Xing Su, Ralph P. Mason

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Semiconductor QDs are being developed as fluorescent tags for biomedical applications such as imaging, targeting, therapeutic carriers, drug delivery, nanomedicine, and in vitro and in vivo biological labeling. However, potential toxicity and clearance of semiconductor QDs in biological systems are of concern. We have tested toxicity and clearance in vitro and in vivo (subcutaneous) of CdTe and CdHgTe semiconductor QDs in human breast cancer MCF7 and MBA-MD-231 cells and prostate cancer PC3 cells over a period of 40 days. Our results show that both CdTe and CdHgTe QDs are cytotoxic to human breast and prostate cancer cells. CdHgTe ODs were cleared rapidly from the site of injection, while CdTe were still detectable 18 days after injection, but were cleared by 30 days.

Original languageEnglish (US)
Pages (from-to)524-528
Number of pages5
JournalJournal of Biomedical Nanotechnology
Volume4
Issue number4
DOIs
Publication statusPublished - Dec 2008

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Keywords

  • CdHgTe
  • CdTe
  • Clearance
  • Semiconductor QDs
  • Toxicity

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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