In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features

Zhan Zhou, Yuhui Zheng, Chengcheng Zhang, Jinwei Gao, Yiping Tang, Qianming Wang

Research output: Contribution to journalArticle

Abstract

Carbonaceous materials have long been developed to utilize “nano-spaces” and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed. We have developed a theranostic platform based on photosensitizer-conjugated carbon nanostructures and this system has been applied in an animal model. In addition, a negligible toxicity of CNH-Pyro was found in body weight experiments and histopathological examination of the major organs.

Original languageEnglish (US)
Pages (from-to)1329-1336
Number of pages8
JournalPhotochemical and Photobiological Sciences
Volume17
Issue number10
DOIs
Publication statusPublished - Jan 1 2018

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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