In vitro-in vivo discordance with humanized piperacillin-tazobactam exposures against piperacillin-tazobactam-resistant/pan-β-lactam-susceptible Klebsiella pneumoniae strains

S. M. Stainton, M. L. Monogue, D. P. Nicolau

Research output: Contribution to journalArticle

6 Scopus citations


Recent findings have identified Klebsiella pneumoniae strains that are pan-β-lactam susceptible (PBL-S) but piperacillin-tazobactam resistant (TZP-R) in vitro. We assessed the efficacy of a humanized exposure of piperacillin-tazobactam (TZP) against 12 TZP-R/PBL-S K. pneumoniae isolates in an immunocompromised murine lung infection model. Discordance between the in vitro resistance profile and the in vivo efficacy of human-simulated TZP exposures against this phenotypic profile was observed. Additional studies are required to define the clinical implications of these TZP-R/PBL-S strains.

Original languageEnglish (US)
Article numbere00491
JournalAntimicrobial Agents and Chemotherapy
Issue number7
Publication statusPublished - Jul 2017
Externally publishedYes



  • Antibiotic resistance
  • Klebsiella pneumoniae
  • Piperacillin-tazobactam

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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