Abstract
Recent findings have identified Klebsiella pneumoniae strains that are pan-β-lactam susceptible (PBL-S) but piperacillin-tazobactam resistant (TZP-R) in vitro. We assessed the efficacy of a humanized exposure of piperacillin-tazobactam (TZP) against 12 TZP-R/PBL-S K. pneumoniae isolates in an immunocompromised murine lung infection model. Discordance between the in vitro resistance profile and the in vivo efficacy of human-simulated TZP exposures against this phenotypic profile was observed. Additional studies are required to define the clinical implications of these TZP-R/PBL-S strains.
Original language | English (US) |
---|---|
Article number | e00491 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 61 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2017 |
Externally published | Yes |
Keywords
- Antibiotic resistance
- Klebsiella pneumoniae
- Piperacillin-tazobactam
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases