In vitro-in vivo discordance with humanized piperacillin-tazobactam exposures against piperacillin-tazobactam-resistant/pan-β-lactam-susceptible Escherichia coli

M. L. Monogue, D. P. Nicolau

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Recent findings have identified Escherichia coli strains that are pan-β-lactam susceptible (PBL-S) but piperacillin-tazobactam resistant (TZP-R) in vitro. We assessed the in vivo significance of this resistance profile in a neutropenic murine pneumonia model using humanized exposures of TZP with 18 clinical E. coli isolates, 8 TZP-S/PBL-S and 10 genotypically confirmed TZP-R/PBL-S. Despite phenotypically and genotypically defined resistance, TZP displayed efficacy against these isolates. Additional studies are required to define the clinical implications of these TZP-R/PBL-S strains.

Original languageEnglish (US)
Pages (from-to)7527-7529
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume60
Issue number12
DOIs
StatePublished - Dec 2016
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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