In vitro induction of specific unresponsiveness against the 2,4,6 trinitrophenyl determinant. I. The induction of unresponsiveness

J. Kettman

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11 Scopus citations


A state of unresponsiveness against the hapten 2,4,6 trinitrophenyl (TNP) can be induced in a mouse spleen cell suspension by incubation in vitro with TMP human serum albumin (HSA), a polyvalent but apparently non immunogenic (in vitro) molecule. The depression is specific for the hapten since cells treated with TNP HSA and cultured with TNP sheep red blood cells (SRBC) show normal anti SRBC responses. The precursors of cells making anti TNP antibody of higher avidity appear to be suppressed selectively. The mechanism of the induction of this specific unresponsiveness remains obscure.

Original languageEnglish (US)
Pages (from-to)1139-1148
Number of pages10
JournalJournal of Immunology
Issue number3
StatePublished - 1974


ASJC Scopus subject areas

  • Immunology

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