TY - JOUR
T1 - In vitro metabolism of 7α-methyl-19-nortestosterone by rat liver, prostate, and epididymis
AU - Agarwal, A. K.
AU - Monder, C.
PY - 1988/11
Y1 - 1988/11
N2 - The in vitro metabolism of 7α-methyl-19-nortestosterone (7α-methyl-3-oxo-estr-4-ene-17β-ol) was investigated in male rat liver, ventral prostate, and epididymis. Three metabolites were recovered from the liver incubation: 7α-methylestr- 4-ene-3,17-dione, 7α-methyl-5j3-estrane-3,17β-diol, and 7αmethyl- 3-oxo-estr-4-ene-16,17j8-diol, whereas prostate and epididymis did not perceptibly metabolize the steroid. The kinetics of metabolism in liver differed significantly from those of testosterone or 19-nortestosterone. About 85% of the 7α-methyl- 19-nortestosterone added was recovered at the end of 30 min of incubation. We conclude that the androgenic potency of 7α-methyl- 19-nortestosterone is not dependent on its further conversion to 5α-dihydro-metabolites.
AB - The in vitro metabolism of 7α-methyl-19-nortestosterone (7α-methyl-3-oxo-estr-4-ene-17β-ol) was investigated in male rat liver, ventral prostate, and epididymis. Three metabolites were recovered from the liver incubation: 7α-methylestr- 4-ene-3,17-dione, 7α-methyl-5j3-estrane-3,17β-diol, and 7αmethyl- 3-oxo-estr-4-ene-16,17j8-diol, whereas prostate and epididymis did not perceptibly metabolize the steroid. The kinetics of metabolism in liver differed significantly from those of testosterone or 19-nortestosterone. About 85% of the 7α-methyl- 19-nortestosterone added was recovered at the end of 30 min of incubation. We conclude that the androgenic potency of 7α-methyl- 19-nortestosterone is not dependent on its further conversion to 5α-dihydro-metabolites.
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U2 - 10.1210/endo-123-5-2187
DO - 10.1210/endo-123-5-2187
M3 - Article
C2 - 2971524
AN - SCOPUS:0023775732
SN - 0013-7227
VL - 123
SP - 2187
EP - 2193
JO - Endocrinology
JF - Endocrinology
IS - 5
ER -