In vitro study of cytotoxic factors against endothelium in childhood dermatomyositis

S. T. Iannaccone, D. Bowen, A. Yarom, G. Ciraolo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In a previous report we showed that leukocytes from a group of patients with childhood dermatomyositis (CDM) were not cytotoxic toward cultured normal human skeletal muscle cells. Blood products from 11 patients with CDM and 12 age- and sex-matched controls were tested for cytotoxicity toward human endothelium using a chromium 51 assay. Mixed lymphocytes, monocytes, and serum alone or in combination did not produce endothelial cell death. The combination of serum and leukocytes, however, did produce some cytotoxic effects in three of 11 patients with CDM. We conclude that those factors tested in vitro are not responsible for the endothelial cell death but together may produce cytotoxic changes in some patients.

Original languageEnglish (US)
Pages (from-to)862-864
Number of pages3
JournalArchives of Neurology
Volume41
Issue number8
StatePublished - 1984

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Dermatomyositis
Endothelium
Leukocytes
Cell Death
Endothelial Cells
Chromium
Serum
Muscle Cells
Monocytes
Skeletal Muscle
Lymphocytes
In Vitro Techniques
Childhood
Cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

In vitro study of cytotoxic factors against endothelium in childhood dermatomyositis. / Iannaccone, S. T.; Bowen, D.; Yarom, A.; Ciraolo, G.

In: Archives of Neurology, Vol. 41, No. 8, 1984, p. 862-864.

Research output: Contribution to journalArticle

Iannaccone, S. T. ; Bowen, D. ; Yarom, A. ; Ciraolo, G. / In vitro study of cytotoxic factors against endothelium in childhood dermatomyositis. In: Archives of Neurology. 1984 ; Vol. 41, No. 8. pp. 862-864.
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