@article{736a3cc5b2b2465a981cdcfa83d67b77,
title = "In vivo administration of Fab′ fragments of anti-L3T4 (GK1.5) antibody inhibits the T helper cell function of murine lymph node cells",
abstract = "The effect of intravenous injection of Fab′ fragments of anti-L3T4 antibody (GK1.5 monoclonal antibody) into mice was studied. This treatment depleted L3T4+ cells from the popliteal lymph nodes of keyhole-limpet hemocyanin-primed mice. The T cells that remained were unable to provide help to antigen-specific B cells in vitro. The results obtained using Fab′ fragments were comparable with those using intact anti-L3T4 antibody and demonstrate that either form of GK1.5 is a potentially useful immunosuppressive agent in mice.",
author = "Street, {Nancy E.} and Koichi Uyemura and Sanders, {Virginia M.} and Uhr, {Jonathan W.} and Vitetta, {Ellen S.}",
note = "Funding Information: {\textquoteright} This work is supported by NIH Grants AI-12789 and AI-l 1851 and Grant I-0947 from the Welch Foundation. 2 Present address: DNAX Research Institute of Molecular and Cellular Biology, Inc., Palo Alto, CA 94304. 3 To whom correspondence should be addressed: Department of Microbiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX 75235. 4 Abbreviations used: ADCC, antibody-dependent cell-mediated cytotoxicity; FACS, fluorescent activated cell sorter; FCS, fetal calf serum; FITC, fluorescein isothiocyanate; KLH, keyhole-limpet hemocyanin; MoAb, monoclonal antibody; NRtIg, normal rat immunoglobulin G, PBS, phosphate-buffered saline; RAMIg, rabbit anti-mouse Ig; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; Tu , T helper cell; TNP-ABC, trinitrophenyl antigen-binding cells.",
year = "1989",
month = apr,
day = "15",
doi = "10.1016/0008-8749(89)90175-5",
language = "English (US)",
volume = "120",
pages = "75--81",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",
}