In vivo administration of Fab′ fragments of anti-L3T4 (GK1.5) antibody inhibits the T helper cell function of murine lymph node cells

Nancy E. Street, Koichi Uyemura, Virginia M. Sanders, Jonathan W. Uhr, Ellen S. Vitetta

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2 Scopus citations


The effect of intravenous injection of Fab′ fragments of anti-L3T4 antibody (GK1.5 monoclonal antibody) into mice was studied. This treatment depleted L3T4+ cells from the popliteal lymph nodes of keyhole-limpet hemocyanin-primed mice. The T cells that remained were unable to provide help to antigen-specific B cells in vitro. The results obtained using Fab′ fragments were comparable with those using intact anti-L3T4 antibody and demonstrate that either form of GK1.5 is a potentially useful immunosuppressive agent in mice.

Original languageEnglish (US)
Pages (from-to)75-81
Number of pages7
JournalCellular Immunology
Issue number1
Publication statusPublished - Apr 15 1989


ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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