In vivo assessment of changes in air and tissue volumes after pneumonectomy

S. Takeda, E. Y. Wu, R. H. Epstein, A. S. Estrera, C. C W Hsia

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27 Scopus citations

Abstract

We examined the progression and topographical distribution of postpneumonectomy volume changes in immature foxhounds undergoing right pneumonectomy (R-Pnx, n = 5)or sham pneumonectomy (Sham, n = 6) at 2 mo of age and subsequently raised to maturity. Volumes of lung air (Vair) and tissue (Vti) were estimated by computerized tomography (CT) scan at 7, 22, and 52 wk after surgery at a transpulmonary pressure of 20 cmH2O. Estimates of Vti by CT scan included both septal tissue as well as nonseptal tissue (small- and medium-sized airways and blood vessels); these were compared with estimates of septal Vti by an acetylene rebreathing (Rb) method. We found significant correlations between these techniques (Vair(CT) = 0.83 Vair(Rb) + 275, R = 0.97; Vti(CT) = 1.62 Vti(Rb) - 30, R = 0.81). Extravascular septal Vti returned to normal 7 wk after R-Pnx and remained normal up to maturity. Nonseptal Vti remained significantly below normal. The greatest increase in Vti occurred in the midlung region just cephalad and caudal to the heart. After an early period of accelerated tissue growth after R-Pnx, the rate of septal tissue growth matched that of somatic growth, whereas nonseptal tissue growth lagged behind. Compensatory growth of the remaining left lung was not associated with selective alterations in thoracic development.

Original languageEnglish (US)
Pages (from-to)1340-1348
Number of pages9
JournalJournal of applied physiology
Volume82
Issue number4
DOIs
StatePublished - Apr 1997

Keywords

  • acetylene rebreathing technique
  • compensatory lung growth
  • computerized tomographic scan
  • lung air volume
  • septal lung tissue volume

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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