In vivo assessment of pituitary gland volume with magnetic resonance imaging: The effect of age

S. N. Lurie, P. M. Doraiswamy, M. M. Husain, O. B. Boyko, E. H. Ellinwood, G. S. Figiel, K. R R Krishnan

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations

Abstract

We used sagittal and coronal T1 weighted magnetic resonance images, at 1.5 Tesla, to measure the height, width, length, and cross-sectional area and to generate two estimates of pituitary gland volume in 35 normal volunteers aged 26-79 yr (19 females and 16 males). Subjects over 50 yr of age had significantly smaller pituitary gland height (P = 0.03), area (P = 0.04), and volume (P = 0.04) than those under 50 yr (by two-tailed t test). Overall, age was negatively correlated with pituitary volume (V1: r = -0.51; P = 0.003; V2: r = -0.47; P = 0.008), area (r = -0.43; P = 0.009), and height (r = -0.46; P = 0.005), but not with pituitary length or width. There were no statistically significant differences in pituitary size between men and women (by two-tailed t test). These findings suggest that pituitary gland height provides a good single measure for the assessment of pituitary gland size and that age must be controlled for in studies of pituitary gland size.

Original languageEnglish (US)
Pages (from-to)505-508
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume71
Issue number2
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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