In vivo brain myo-inositol levels in children with Down syndrome

Gerard T. Berry, Zhiyue J. Wang, Steffi F. Dreha, Brenda M. Finucane, Robert A. Zimmerman

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The Na+/myo-inositol cotransporter (SLC5A3) gene, located on the long arm of human chromosome 21, may play a key role in osmoregulation including the regulation of levels of the 'idiogenic osmole,' myo-inositol, in brain cells. To determine whether the levels of myo-inositol are increased in the basal ganglia of children with Down syndrome, we performed in vivo brain hydrogen 1-nuclear magnetic resonance or 1H-magnetic resonance spectroscopy and measured plasma osmolality in a cohort of children with trisomy 21. Myo- inositol is elevated in the corpus striatum of infants and children with Down syndrome, even in the absence of hypertonic stress.

Original languageEnglish (US)
Pages (from-to)94-97
Number of pages4
JournalJournal of Pediatrics
Volume135
Issue number1
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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