In vivo breast imaging with diffuse optical tomography based on higher-order diffusion equations

Yong Xu, Xuejun Gu, Laurie L. Fajardo, Huabei Jiang

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We report on in vivo absorption and scattering imaging of a human breast cyst and implant, using a reconstruction algorithm based on our third-order diffusion equations. To validate these in vivo images, a series of phantom experiments were conducted, in which we used low-absorbing and low-scattering heterogeneities to mimic a breast cyst or implant. These heterogeneities or targets were composed of pure water or a mixture of water and very dilute Intralipid (0.05% and 0.1%). The phantom experiments confirmed the quantitative imaging capability of our improved algorithm for reconstructing heterogeneities where the conventional diffusion approximation is inadequate. Pilot clinical results from female volunteers indicate that enhanced diffuse optical tomography can quantitatively image findings such as breast cysts or implants in which the absorption and scattering coefficients are usually low.

Original languageEnglish (US)
Pages (from-to)3163-3169
Number of pages7
JournalApplied Optics
Volume42
Issue number16
DOIs
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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