In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 tesla

Changho Choi, Ivan Dimitrov, Deborah Douglas, Chenguang Zhao, Halima Hawesa, Subroto Ghose, Carol A. Tamminga

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A single-voxel proton magnetic resonance spectroscopy (1H-MRS) filtering strategy for in vivo detection of serine (Ser) in human brain at 7T is proposed. Spectral difference of coupled resonances arising from different subecho times of triple refocusing at a constant total echo time (TE) was utilized to detect the Ser multiplet and cancel the overlapping creatine (Cr) 3.92-ppm singlet via difference editing. Dependence of the Ser signal on subecho times was investigated using density-matrix simulation incorporating the slice-selective radio frequency (RF) pulses. The simulation indicated that the difference-edited Ser CH2 multiplet at ∼3.96 ppm is maximized with (TE1, TE2, TE3) = (54, 78, 78) and (36, 152, 22) ms. The edited Ser peak amplitude was estimated, with both numerical and phantom analyses of the performance, as 83% with respect to 90° acquisition for a localized volume, ignoring relaxation effects. From the area ratio of the edited Ser and unedited Cr 3.03-ppm peaks, assuming identical T1 and T2 between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 ± 0.2 (mean ± SD; N = 6).

Original languageEnglish (US)
Pages (from-to)1042-1046
Number of pages5
JournalMagnetic Resonance in Medicine
Volume62
Issue number4
DOIs
StatePublished - Oct 2009

Fingerprint

Serine
Creatine
Brain
Proton Magnetic Resonance Spectroscopy
Frontal Lobe
Radio

Keywords

  • H-MRS
  • Difference editing
  • Human brain
  • Serine
  • Triple refocusing

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 tesla. / Choi, Changho; Dimitrov, Ivan; Douglas, Deborah; Zhao, Chenguang; Hawesa, Halima; Ghose, Subroto; Tamminga, Carol A.

In: Magnetic Resonance in Medicine, Vol. 62, No. 4, 10.2009, p. 1042-1046.

Research output: Contribution to journalArticle

@article{924cfb72506e4f8793dbe240f35f0029,
title = "In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 tesla",
abstract = "A single-voxel proton magnetic resonance spectroscopy (1H-MRS) filtering strategy for in vivo detection of serine (Ser) in human brain at 7T is proposed. Spectral difference of coupled resonances arising from different subecho times of triple refocusing at a constant total echo time (TE) was utilized to detect the Ser multiplet and cancel the overlapping creatine (Cr) 3.92-ppm singlet via difference editing. Dependence of the Ser signal on subecho times was investigated using density-matrix simulation incorporating the slice-selective radio frequency (RF) pulses. The simulation indicated that the difference-edited Ser CH2 multiplet at ∼3.96 ppm is maximized with (TE1, TE2, TE3) = (54, 78, 78) and (36, 152, 22) ms. The edited Ser peak amplitude was estimated, with both numerical and phantom analyses of the performance, as 83{\%} with respect to 90° acquisition for a localized volume, ignoring relaxation effects. From the area ratio of the edited Ser and unedited Cr 3.03-ppm peaks, assuming identical T1 and T2 between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 ± 0.2 (mean ± SD; N = 6).",
keywords = "H-MRS, Difference editing, Human brain, Serine, Triple refocusing",
author = "Changho Choi and Ivan Dimitrov and Deborah Douglas and Chenguang Zhao and Halima Hawesa and Subroto Ghose and Tamminga, {Carol A.}",
year = "2009",
month = "10",
doi = "10.1002/mrm.22079",
language = "English (US)",
volume = "62",
pages = "1042--1046",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 tesla

AU - Choi, Changho

AU - Dimitrov, Ivan

AU - Douglas, Deborah

AU - Zhao, Chenguang

AU - Hawesa, Halima

AU - Ghose, Subroto

AU - Tamminga, Carol A.

PY - 2009/10

Y1 - 2009/10

N2 - A single-voxel proton magnetic resonance spectroscopy (1H-MRS) filtering strategy for in vivo detection of serine (Ser) in human brain at 7T is proposed. Spectral difference of coupled resonances arising from different subecho times of triple refocusing at a constant total echo time (TE) was utilized to detect the Ser multiplet and cancel the overlapping creatine (Cr) 3.92-ppm singlet via difference editing. Dependence of the Ser signal on subecho times was investigated using density-matrix simulation incorporating the slice-selective radio frequency (RF) pulses. The simulation indicated that the difference-edited Ser CH2 multiplet at ∼3.96 ppm is maximized with (TE1, TE2, TE3) = (54, 78, 78) and (36, 152, 22) ms. The edited Ser peak amplitude was estimated, with both numerical and phantom analyses of the performance, as 83% with respect to 90° acquisition for a localized volume, ignoring relaxation effects. From the area ratio of the edited Ser and unedited Cr 3.03-ppm peaks, assuming identical T1 and T2 between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 ± 0.2 (mean ± SD; N = 6).

AB - A single-voxel proton magnetic resonance spectroscopy (1H-MRS) filtering strategy for in vivo detection of serine (Ser) in human brain at 7T is proposed. Spectral difference of coupled resonances arising from different subecho times of triple refocusing at a constant total echo time (TE) was utilized to detect the Ser multiplet and cancel the overlapping creatine (Cr) 3.92-ppm singlet via difference editing. Dependence of the Ser signal on subecho times was investigated using density-matrix simulation incorporating the slice-selective radio frequency (RF) pulses. The simulation indicated that the difference-edited Ser CH2 multiplet at ∼3.96 ppm is maximized with (TE1, TE2, TE3) = (54, 78, 78) and (36, 152, 22) ms. The edited Ser peak amplitude was estimated, with both numerical and phantom analyses of the performance, as 83% with respect to 90° acquisition for a localized volume, ignoring relaxation effects. From the area ratio of the edited Ser and unedited Cr 3.03-ppm peaks, assuming identical T1 and T2 between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 ± 0.2 (mean ± SD; N = 6).

KW - H-MRS

KW - Difference editing

KW - Human brain

KW - Serine

KW - Triple refocusing

UR - http://www.scopus.com/inward/record.url?scp=70349616317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349616317&partnerID=8YFLogxK

U2 - 10.1002/mrm.22079

DO - 10.1002/mrm.22079

M3 - Article

C2 - 19526507

AN - SCOPUS:70349616317

VL - 62

SP - 1042

EP - 1046

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 4

ER -