@inproceedings{b8a4135296484bfd852cf2d12831605a,
title = "In vivo dual-modality imaging of lymphatic systems using indocyanine green in rats: Three-dimensional photoacoustic imaging and planar fluorescence imaging",
abstract = "The purpose of this study is to map non-invasively sentinel lymph nodes (SLNs) and lymphatic vessels of rats in vivo using FDA-approved indocyanine green (ICG) and two non-ionizing imaging modalities: volumetric spectroscopic photoacoustic (PA) imaging, which measures optical absorption, and planar fluorescence imaging, which measures fluorescent emission. SLNs and lymphatic vessels were clearly visible after a 0.2 ml-intradermal-injection of 1 mM ICG in both imaging systems. We also imaged deeply positioned lymph nodes in vivo by layering biological tissues on top of rats. These two modalities, when used together with ICG, have the potential to map SLNs in axillary staging and to study tumor metastasis in breast cancer patients.",
keywords = "Axillary lymph node dissection, Breast cancer, Photoacoustic tomography, Planar fluorescence imaging, Sentinel lymph node biopsy",
author = "Chulhong Kim and Song, {Kwang Hyun} and Wang, {Lihong V.}",
year = "2010",
month = feb,
day = "11",
doi = "10.1117/12.841964",
language = "English (US)",
isbn = "9780819479600",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2010 ; Conference date: 24-01-2010 Through 26-01-2010",
}