In vivo estimation of transverse relaxation time constant (T 2 ) of 17 human brain metabolites at 3T

Patrik O. Wyss, Claudio Bianchini, Milan Scheidegger, Ioannis A. Giapitzakis, Andreas Hock, Alexander Fuchs, Anke Henning

Research output: Contribution to journalArticle

12 Scopus citations


Purpose: The transverse relaxation times T 2 of 17 metabolites in vivo at 3T is reported and region specific differences are addressed. Methods: An echo-time series protocol was applied to one, two, or three volumes of interest with different fraction of white and gray matter including a total number of 106 healthy volunteers and acquiring a total number of 128 spectra. The data were fitted with the 2D fitting tool ProFit2, which included individual line shape modeling for all metabolites and allowed the T 2 calculation of 28 moieties of 17 metabolites. Results: The T 2 of 10 metabolites and their moieties have been reported for the first time. Region specific T 2 differences in white and gray matter enriched tissue occur in 16 of 17 metabolites examined including single resonance lines and coupled spin systems. Conclusion: The relaxation time T 2 is regions specific and has to be considered when applying tissue composition correction for internal water referencing. Magn Reson Med 80:452–461, 2018.

Original languageEnglish (US)
Pages (from-to)452-461
Number of pages10
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Aug 2018
Externally publishedYes


  • 3T
  • gray and white matter
  • human
  • in vivo
  • T correction
  • T relaxation time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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