In vivo MRS measurement of deoxymyoglobin in human forearms

Z. Wang, E. A. Noyszewski, J. S. Leigh

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

In vivo MRS measurement of deoxymyoglobin (deoxy‐Mb) in human forearms was performed by observing the N‐δ proton of F8 proximal histidine. The concentration of deoxy‐Mb reflects the oxygen level in the muscle. In resting muscles, the deoxy‐Mb level was below the detection sensitivity. When ischemia was introduced by arterial occlusion, the time‐resolved NMR spectra (with 1 min resolution) was recorded to follow the change in the deoxy‐Mb signal. The result shows that deoxy‐Mb signal builds up and levels off within 6 min. This technique may be used to study bioenergetics of muscle during exercise and under pathological conditions. © 1990 Academic Press, Inc.

Original languageEnglish (US)
Pages (from-to)562-567
Number of pages6
JournalMagnetic resonance in medicine
Volume14
Issue number3
DOIs
StatePublished - Jun 1990

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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